Effective Targeting of the Epidermal Growth Factor Receptor (EGFR) for Treating Oral Cancer: A Promising Approach

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dc.contributor.author Ribeiro, Flavia Andressa Pidone [UNIFESP]
dc.contributor.author Noguti, Juliana [UNIFESP]
dc.contributor.author Oshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.author Ribeiro, Daniel Araki [UNIFESP]
dc.date.accessioned 2018-06-15T13:50:15Z
dc.date.available 2018-06-15T13:50:15Z
dc.date.issued 2014-04-01
dc.identifier http://ar.iiarjournals.org/content/34/4/1547.long
dc.identifier.citation Anticancer Research. Athens: Int Inst Anticancer Research, v. 34, n. 4, p. 1547-1552, 2014.
dc.identifier.issn 0250-7005
dc.identifier.uri http://repositorio.unifesp.br/11600/42601
dc.description.abstract Oral cancer is a serious problem growing in incidence in many parts of the world; it is considered the sixth most common cancer and despite sophisticated surgical and radiotherapeutic modalities, oral squamous cell carcinoma, which represents 90% of oral cancers, is characterized by poor prognosis and a low survival rate. The Epidermal growth factor receptor family of receptor tyrosine kinases (RTK) comprises of four distinct receptors: the EGFR (also known as ErbB-1/HER1), ErbB-2 (neu, HER2), ErbB-3 (HER3) and ErbB-4 (HER4). Several studies have been published on the role of EGFR in the pathogenesis of oral carcinoma. The aim of the present review is to describe the role of EGFR pathway in oral cancer with special focus on its role during the carcinogenesis process as a result of therapeutic approaches of EGFR in oral cancer. The EGFR is a 170-kDa cell-surface protein involved in many biological processes, such as proliferation, migration, DNA synthesis and adhesion. Overexpression of EGFR results in a poor prognosis in oral cancer and its activation is associated with the malignant phenotype, inhibition of apoptosis and increased metastatic potential. EGFR variations and mutations have been correlated with tumor formation, and possibly alter the therapeutic efficacy of EGFR inhibitors. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 1547-1552
dc.language.iso eng
dc.publisher Int Inst Anticancer Research
dc.relation.ispartof Anticancer Research
dc.rights Acesso aberto
dc.subject Epidermal growth factor receptor en
dc.subject oral cancer en
dc.subject review en
dc.title Effective Targeting of the Epidermal Growth Factor Receptor (EGFR) for Treating Oral Cancer: A Promising Approach en
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Pathol, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Pathol, BR-11060001 Santos, SP, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000334089200009



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