The Role of Canonical WNT Signaling Pathway in Oral Carcinogenesis: A Comprehensive Review

The Role of Canonical WNT Signaling Pathway in Oral Carcinogenesis: A Comprehensive Review

Author Noguti, Juliana Autor UNIFESP Google Scholar
Moura, Carolina Foot Gomes de Autor UNIFESP Google Scholar
Hossaka, Thais Ayako Autor UNIFESP Google Scholar
Franco, Marcello Fabiano de Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Dedivitis, Rogério Aparecido Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ana Costa Hosp & Santa Casa Misericordia Santos
Abstract Oral cancer is a common neoplasm worldwide. The incidence and mortality have also increased in recent decades. It is characterized by poor prognosis and a low survival rate despite sophisticated surgical and radiotherapeutic modalities. The WNTs comprise a large family of highly conserved growth factors associated with a number of functions. In this review, we focus largely on the canonical pathway, revealing the recent findings, in oral cancer research, thereby raising our understanding of the mechanisms of this crucial signaling in several cellular activities.
Keywords WNT
Oral cancer
Apoptosis
Review
Language English
Date 2012-03-01
Published in Anticancer Research. Athens: Int Inst Anticancer Research, v. 32, n. 3, p. 873-878, 2012.
ISSN 0250-7005 (Sherpa/Romeo, impact factor)
Publisher Int Inst Anticancer Research
Extent 873-878
Origin https://ar.iiarjournals.org/content/32/3/873.long
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000301619200024
URI https://repositorio.unifesp.br/11600/42598

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