C-MYC locus amplification as metastasis predictor in intestinal-type gastric adenocarcinomas: CGH study in Brazil

C-MYC locus amplification as metastasis predictor in intestinal-type gastric adenocarcinomas: CGH study in Brazil

Author Burbano, Rommel Rodríguez Autor UNIFESP Google Scholar
Assumpcao, Paulo Pimentel de Autor UNIFESP Google Scholar
Leal, Mariana Ferreira Autor UNIFESP Google Scholar
Calcagno, Danielle Queiroz Autor UNIFESP Google Scholar
Guimaraes, Adriana Costa Google Scholar
Khayat, Andre Salim Google Scholar
Takeno, Sylvia Satomi Autor UNIFESP Google Scholar
Chen, Elizabeth Suchi Autor UNIFESP Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Institution Univ Fed Para
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: The genetic events involved in gastric cancer, the third most frequent cancer in the world with a high incidence in Para State, Brazil, remain largely unknown. Materials and Methods: Twenty-one primary gastric adenocarcinomas were investigated by comparative genomic hybridization (CGH) and the relationships between genomic abnormalities and histopathological features were evaluated. Results: Eighty-one percent of cases presented DNA copy-number changes. Chromosomal gains were the most frequent finding, losses occurring only in the diffuse type. The main copy-number gains were on chromosome 8, principally on 8q24.1 (8121 cases), 8p21 (3121) and 8p23.28p12 (2121). Gain of region 8q24.1, where C-WC is located, was the main finding, exclusively in the intestinal type with metastasis. Conclusion: C-MYC locus amplification may be predictor of aggressiveness in intestinal-type gastric cancer, playing an important role in its development and progression. Moreover, other genes on 8q24 should be investigated. Gastric adenocarcinomas of differing histopathological features were associated with distinct genetic alterations, supporting the hypothesis that they evolve through distinct genetic pathways.
Keywords gastric cancer
comparative genomic hybridization
Language English
Date 2006-07-01
Published in Anticancer Research. Athens: Int Inst Anticancer Research, v. 26, n. 4B, p. 2909-2914, 2006.
ISSN 0250-7005 (Sherpa/Romeo, impact factor)
Publisher Int Inst Anticancer Research
Extent 2909-2914
Origin http://ar.iiarjournals.org/content/26/4B/2909.abstract
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000241391600018
URI http://repositorio.unifesp.br/11600/42593

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