Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma

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Calcagno, Danielle Queiroz [UNIFESP]
Leal, Mariana Ferreira [UNIFESP]
Takeno, Sylvia Satomi [UNIFESP]
Assumpcao, Paulo Pimentel de [UNIFESP]
Demachki, Samia
Smith, Marilia de Arruda Cardoso [UNIFESP]
Burbano, Rommel Rodríguez [UNIFESP]
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Background: Gastric cancer is the third most frequent type of neoplasia. In northern Brazil, the State of Para has a high incidence of this type of neoplasia. Limited data are available so far on the genetic events involved in this disease. Materials and Methods: Dual-color fluorescence in situ hybridization (FISH) for the C-MYC gene and chromosome 8 centromere was performed in 11 gastric adenocarcinomas. Results: All cases showed aneuploidy of chromosome 8 and C-MYC amplification, in both the diffuse and the intestinal histopathological types of Lauren. No, correlation was found between polysomy 8 and the histopathological characteristics of the tumors. C-MYC amplification, like homogeneously-stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Translocation of C-MYC was observed only in the diffuse-type. Conclusion: Chromosome 8 can be used as a marker in the diagnosis of gastric adenocarcinoma. The C-WC oncogene requires further studies in order to verify if it is, when amplified, an etiological cause of transformation or a consequence of the proliferation process.
Anticancer Research. Athens: Int Inst Anticancer Research, v. 25, n. 6B, p. 4069-4074, 2005.