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dc.contributor.authorAtala, Magda M.
dc.contributor.authorGoulart, Alessandra [UNIFESP]
dc.contributor.authorGuerra, Grazia Maria
dc.contributor.authorMostarda, Cristiano [UNIFESP]
dc.contributor.authorRodrigues, Bruno
dc.contributor.authorMello, Priscila R.
dc.contributor.authorCasarine, Dulce Elena [UNIFESP]
dc.contributor.authorIrigoyen, Maria Claudia [UNIFESP]
dc.contributor.authorPereira, Alexandre C.
dc.contributor.authorConsolim-Colombo, Fernanda Marciano
dc.date.accessioned2018-06-15T13:20:18Z
dc.date.available2018-06-15T13:20:18Z
dc.date.issued2015-01-01
dc.identifierhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346532/
dc.identifier.citationAmerican Journal Of Translational Research. Madison: E-century Publishing Corp, v. 7, n. 1, p. 153-161, 2015.
dc.identifier.issn1943-8141
dc.identifier.urihttp://repositorio.unifesp.br/11600/42402
dc.description.abstractThe association between functional beta(2) adrenergic receptor (beta(2)-AR) polymorphisms and cardiac autonomic modulation is still unclear. Thus, two common polymorphisms in the beta(2)-AR gene (Gln27Glu beta(2) and Arg16Gly beta(2)) were studied to determine whether they might affect tonic and reflex cardiac sympathetic activity in healthy young subjects. A total of 213 healthy young white subjects of both genders (53% female), aged 18-30 years (23.5 +/- 3.4 y), had their continuous blood pressure curves noninvasively recorded by Finometer at baseline, and other hemodynamic parameters, as cardiac autonomic modulation, baroreflex sensitivity, and allele, genotype, and diplotype frequencies calculated. Associations were made between Arg16Gly beta(2) and Gln27Glu beta(2) polymorphisms and between beta(2)-AR diplotypes and all variables. The heart rate was significantly lower (P<0.001) in the presence of homozygous Arg/Arg alleles (60.9 +/- 1.5 bpm) than in that of Arg/Gly heterozygotes (65.9 +/- 1.0 bpm) or Gly/Gly homozygotes (66.3 +/- 1.2 bpm). Homozygous carriers of Arg16 allele had an alpha index (19.2 +/- 1.3) significantly higher (P<0.001) than that of the subjects with the Gly allele Gly/Gly ( 14.5 +/- 0.7) or Arg/Gly (14.6 +/- 0.7). Furthermore, the recessive Glu27Glu and the heterozygous Gln27Glu genotypes had a higher percentage of low-frequency components (LF%) than the homozygous Gln27Gln (15.1% vs. 16.0% vs. 8.2%, P=0.03, respectively). In healthy young subjects, the presence of beta(2)-AR Arg16 allele in a recessive model was associated with higher baroreflex sensitivity, and increased parasympathetic modulation in studied individuals.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent153-161
dc.language.isoeng
dc.publisherE-century Publishing Corp
dc.relation.ispartofAmerican Journal Of Translational Research
dc.rightsAcesso aberto
dc.subjectbeta(2)-adrenergic polymorphismen
dc.subjectautonomic nervous systemen
dc.subjectcardiac autonomic balanceen
dc.subjectheart rate variabilityen
dc.titleArg16Gly and Gln27Glu beta 2 adrenergic polymorphisms influence cardiac autonomic modulation and baroreflex sensitivity in healthy young Braziliansen
dc.typeArtigo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Maranhao
dc.contributor.institutionUniv Sao Judas Tadeu
dc.contributor.institutionUniv Nove de Julho UNINOVE
dc.description.affiliationUniv Sao Paulo FMUSP, Sch Med, Heart Inst InCor, Hypertens Unit, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo FMUSP, Univ Hosp, Dept Internal Med, Sch Med, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Nefrol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Maranhao, Hosp Materno Infantil, Sao Luis, Brazil
dc.description.affiliationUniv Sao Judas Tadeu, Human Movement Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo FMUSP, Sch Med, Heart Inst InCor, Mol Genet Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Nove de Julho UNINOVE, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Nefrol, Sao Paulo, Brazil
dc.identifier.fileWOS000349843800014.pdf
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000349843800014


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