MicroRNAs in cancer treatment and prognosis
Data
2012-01-01
Autores
Schoof, Claudia Regina Gasque [UNIFESP]
Botelho, Eder Leite da Silva [UNIFESP]
Izzotti, Alberto
Vasques, Luciana dos Reis [UNIFESP]
Orientadores
Tipo
Resenha
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Disturbances in microRNA expression by epigenetic alterations and mutations may promote not only tumorigenesis but also tumor aggressiveness, invasion, metastasis, and resistance to chemotherapy and radiotherapy. Several studies have profiled microRNA expression in normal and tumorigenic tissues, demonstrating a unique microRNA signature, which can be used as a marker for cancer diagnosis and prognosis. This review discusses the importance of microRNAs as regulatory biomolecules involved in cancer, focusing on microRNAs related to cancer invasion, metastasis, epigenetic alterations, chemoresistance, and radioresistance. The identification of both differentially expressed microRNAs in tumors and their target genes provides new tools for gene therapy; the re-expression of microRNAs silenced by cancer development or the silencing of oncogenic microRNAs can be effective in the blockade of cancer-related cell proliferation.
Descrição
Citação
American Journal Of Cancer Research. Madison: E-century Publishing Corp, v. 2, n. 4, p. 414-U136, 2012.