Sensitisation to aeroallergens in Brazilian adolescents living at the periphery of large subtropical urban centres

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Pastorino, Antonio Carlos
Kuschnir, Fabio Chigres
Arruda, Luisa Karla de Paula [UNIFESP]
Casagrande, Rejane Rimazza Dalberto
Souza, Renata Gontijo Lima de
Dias, Gabriela Andrade Coelho
Silveira, H. H. N.
Cunha, Antonio Jose Ledo Alves da
Jacob, Cristina Miuki Abe [UNIFESP]
Solé, Dirceu [UNIFESP]
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Objectives: To evaluate the sensitization to aeroallergens determined by skin prick test (SPT) in Brazilian adolescents, and to correlate its positivity with the diagnosis of asthma and/or rhinitis based on the written questionnaire (WQ) of ISAAC phase III study.Patients and Methods: A total of 996 adolescents (387 boys) were selected by systematic samples. A standard allergen extracts panel (positive/negative control, D pteronyssinus [Dpt], P americana [Pal, B germanica [Bg], dog, cat, fungal and grass mix) was used and its positivity compared with positive responses to asthma, rhinitis or both.Results: Positive SPT to at least one allergen was observed in 466 adolescents (46.8 %), with sensitisation to Dpt in 79.1 %. Positivity to more than one allergen occurred in 232 students (49.8 %). The frequency of positive SPTs was significantly higher among adolescents with asthma (OR = 2.16), rhinitis (OR = 1.69), and asthma and rhinitis (OR = 2.03). Positive SPT to four or more allergens were higher among asthmatics (OR = 2.6) and among adolescents with asthma and rhinitis (OR = 3).Conclusions: A high sensitisation rate to aeroallergens was observed, significantly higher among those with asthma, rhinitis or a combination of both, especially in multiple sensitisations.
Allergologia Et Immunopathologia. Barcelona: Elsevier Doyma Sl, v. 36, n. 1, p. 9-16, 2008.