Maternally acquired immunity in newborns from women infected by the human immunodeficiency virus

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dc.contributor.author Moraes-Pinto, Maria Isabel de [UNIFESP]
dc.contributor.author Farhat, Calil Kairalla [UNIFESP]
dc.contributor.author Carbonare, Solange B.
dc.contributor.author Curti, S. P.
dc.contributor.author Otsubo, MES
dc.contributor.author Lazarotti, D. S.
dc.contributor.author Campagnoli, R. C.
dc.contributor.author Carneiro-Sampaio, Magda Maria Sales
dc.date.accessioned 2018-06-15T12:39:56Z
dc.date.available 2018-06-15T12:39:56Z
dc.date.issued 1993-12-01
dc.identifier http://dx.doi.org/10.1111/j.1651-2227.1993.tb12805.x
dc.identifier.citation Acta Paediatrica. Oslo: Scandinavian University Press, v. 82, n. 12, p. 1034-1038, 1993.
dc.identifier.issn 0803-5253
dc.identifier.uri http://repositorio.unifesp.br/11600/42025
dc.description.abstract Maternally acquired immunity was studied in 16 pairs of human immunodeficiency virus (HIV)-seropositive women and their newborns, and was compared to 18 control mother-newborn pairs. The HIV-infected women had higher IgG levels than the control subjects, but no difference was observed between newborn samples, presumably due to the limited placental IgG transfer in the HIV group. A poor type 2 poliovirus antibody transfer was also noted in this group. The population of newborns lacking demonstrable measles antibodies was higher in the HIV group than in the control group, probably because many of the HIV-infected mothers lacked measles antibodies also. These results show that maternally acquired immunity may be affected to newborns from HIV-infected women, either because of low maternal serum antibody levels or deficient transplacental transfer. If so, the measles vaccine schedule should be revised for these children and the same should be done for future passive immunization regarding fetus protection in pregnant HIV-seropositive women. en
dc.format.extent 1034-1038
dc.language.iso eng
dc.publisher Scandinavian University Press
dc.relation.ispartof Acta Paediatrica
dc.rights Acesso restrito
dc.subject ACQUIRED IMMUNODEFICIENCY SYNDROME en
dc.subject HIV en
dc.subject IMMUNOGLOBULINS en
dc.subject MATERNALLY ACQUIRED IMMUNITY en
dc.subject MEASLES en
dc.subject POLIOMYELITIS en
dc.title Maternally acquired immunity in newborns from women infected by the human immunodeficiency virus en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution INST ADOLFO LUTZ REGISTRO
dc.description.affiliation UNIV SAO PAULO,DEPT IMMUNOL,BR-05508900 SAO PAULO,SP,BRAZIL
dc.description.affiliation ESCOLA PAULISTA MED,DEPT PEDIAT,SAO PAULO,SP,BRAZIL
dc.description.affiliation INST ADOLFO LUTZ REGISTRO,VIROL SERV,SAO PAULO,SP,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED,DEPT PEDIAT,SAO PAULO,SP,BRAZIL
dc.identifier.doi 10.1111/j.1651-2227.1993.tb12805.x
dc.description.source Web of Science
dc.identifier.wos WOS:A1993MT44300008



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