Neurologic outcome after heart transplantation in Chagas' disease - Preliminary results

Neurologic outcome after heart transplantation in Chagas' disease - Preliminary results

Author Malheiros, Suzana Maria Fleury Autor UNIFESP Google Scholar
Gabbai, Alberto Alain Autor UNIFESP Google Scholar
Brucki, Sonia Maria Dozzi Autor UNIFESP Google Scholar
Massaro, Ayrton Roberto Autor UNIFESP Google Scholar
Almeida, Dirceu Rodrigues de Autor UNIFESP Google Scholar
Carvalho, Adriana Ivete Cornita de Autor UNIFESP Google Scholar
Branco, João Nelson Rodrigues Autor UNIFESP Google Scholar
Castelo Filho, Adauto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective - To evaluate the neurologic morbidity after orthotopic heart transplantation (OHT), we examined consecutive Chagas' (Ch) and non-Chagas' (NCh) patients, before and after surgery. Material and methods - We undertook neurological and neuropsychological evaluations in Ch and NCh patients with end-stage cardiac failure, from September 1993 to September 1995. Results - Of 10 Ch patients (mean age=33.6 years; 7 male; mean follow-up=10.8 months) and 13 NCh patients (mean age=50.9 years; 12 male; mean follow-up=15 months) 3 died (rejection and sepsis) without neurological symptoms. Neurologic complications occurred in 4 Ch and 5 NCh patients. Two Ch patients had skin and myocardial Chagas' reactivation successfully treated, without CNS involvement. NPS performance and return to work rates were similar in both groups. Conclusions - Although Ch patients are potentially at a higher risk of Trypanosoma cruzi reactivation, in addition to all known neurologic complications of OHT, early neurologic complications detected in this sample were similar in Ch and NCh patients and could not be specifically related to Chagas' disease.
Keywords heart transplantation
Chagas' disease
postoperative complications
Language English
Date 1997-10-01
Published in Acta Neurologica Scandinavica. Copenhagen: Munksgaard Int Publ Ltd, v. 96, n. 4, p. 252-255, 1997.
ISSN 0001-6314 (Sherpa/Romeo, impact factor)
Publisher Munksgaard Int Publ Ltd
Extent 252-255
Access rights Closed access
Type Article
Web of Science ID WOS:A1997XW50000014

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