Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal (R)) coated polypropylene mesh in rabbits

Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal (R)) coated polypropylene mesh in rabbits

Author Quinino, Reynaldo Martins e Autor UNIFESP Google Scholar
Araujo-Filho, Irami Google Scholar
Lima, Francisco Piganataro Google Scholar
Barbosa, Andre Luis Costa Google Scholar
Maia, Tatiana de Carvalho Google Scholar
Goldenberg, Alberto Autor UNIFESP Google Scholar
Institution Rio Grande do Norte Fed Univ UFRN
Universidade Federal de São Paulo (UNIFESP)
Abstract PURPOSE: To evaluate of postoperative adhesion prevention and inflammatory response to polypropylene mesh, coated with reabsorbable hydrogel of polyethylene glycol (Coseal (R)) in contact with small bowel in an experimental model in rabbits.METHODS: Twenty female rabbits underwent laparotomy to implant two polypropylene meshes, 2x1cm, in the right and left flanks. The right mesh was protected with Coseal (R) spray (Group 1) and the left mesh received no treatment after implantation (Group 2). Thirty days after implantation, the rabbits underwent laparoscopy for adhesion analysis; the prosthesis were removed en bloc with the adjacent tissue for microscopic analysis of inflammation. Statistical analysis used the Mann-Whitney test.RESULTS: There was adhesion formation in five meshes (36%) from Group 1 and in 14 meshes (100%) from Group 2, with statistical significance (p<0.01). There were no differences in the inflammatory response, fibrosis, foreign body reaction, presence of collagen and type of inflammatory cells between the two groups.CONCLUSION: Polypropylene mesh coated with Coseal (R) showed a significantly lower rate of adhesion formation when compared with uncoated meshes, without interfering with inflammatory response.
Keywords Tissue Adhesions
Polyethylene Glycols
Language English
Date 2013-12-01
Published in Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 28, n. 12, p. 807-814, 2013.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 807-814
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000328649900001
SciELO ID S0102-86502013001200001 (statistics in SciELO)

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