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dc.contributor.authorApostolo, Anna
dc.contributor.authorLaveneziana, PierAntonio
dc.contributor.authorPalange, Paolo
dc.contributor.authorAgalbato, Cecilia
dc.contributor.authorMolle, Roberta
dc.contributor.authorPopovic, Dejana
dc.contributor.authorBussotti, Maurizio
dc.contributor.authorInternullo, Mattia
dc.contributor.authorSciomer, Susanna
dc.contributor.authorBonini, Matteo
dc.contributor.authorAlencar, Maria Clara [UNIFESP]
dc.contributor.authorGodinas, Laurent
dc.contributor.authorArbex, Flavio [UNIFESP]
dc.contributor.authorGarcia, Gilles
dc.contributor.authorAlberto Neder, J. [UNIFESP]
dc.contributor.authorAgostoni, Piergiuseppe
dc.identifier.citationInternational Journal of Cardiology. Clare: Elsevier B.V., v. 189, p. 134-140, 2015.
dc.description.abstractBackground: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) coexistence increases morbidity and mortality. the intercept of ventilation ((V) over dotEint) on the (V) over dotE vs. carbon dioxide production ((V) over dot CO2) relationship during exercise has been found to vary in proportion with dead space (VD) in HF. Considering that increased VD is the key pathophysiological abnormality in COPD but a secondary finding in HF we hypothesized that a high (V) over dotEint would be useful in suggesting COPD as HF co-morbidity. Our aim was to assess whether an elevated (V) over dotEint suggests the presence of COPD in HF.Methods: in a multicenter retrospective study, the (V) over dotE-(V) over dotCO(2) relationship was analyzed both as slope and intercept in HF (n = 108), HF-COPD (n = 106) and COPD (n = 95). Patients with pulmonary arterial hypertension (PAH) (n= 85) and healthy subjects (HF) (n= 56) served as positive and negative controls relative to (V) over dotE-(V) over dotCO(2) abnormalities, respectively.Results: Slope and (V) over dotEint varied in opposite directions in all groups (p < 0.05) being (V) over dotE-(V) over dotCO(2) slope highest and lowest in PAH and healthy subjects, respectively. No slope differences were observed among HF, HF-COPD and COPD (32 +/- 7, 31 +/- 7, and 31 +/- 6, respectively). (V)over dotEint was higher in HF-COPD and COPD compared to HF, PAH and controls (4.8 +/- 2.4 L/min, 5.9 +/- 3.0 L/min, 3.0 +/- 2.6 L/min, 2.3 +/- 3.3 L/min and 3.9 +/- 2.5 L/min, respectively; p < 0.01). A (V) over dotEint >= 4.07 L/min identified patients with high probability of having COPD or HF-COPD (sensitivity of 71.6% and specificity of 72.0%).Conclusion: These data provide novel evidence that a high (V) over dotEint (>= 4.07 L/min) should be valued to suggest coexistent COPD in HF patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en
dc.description.sponsorshipCentro Cardiologico Monzino, IRCCS, Milano (Italy)
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Cardiology
dc.rightsAcesso restrito
dc.subjectVentilatory efficiencyen
dc.subjectDead spaceen
dc.subjectHeart failureen
dc.subjectLung diseasesen
dc.titleImpact of chronic obstructive pulmonary disease on exercise ventilatory efficiency in heart failureen
dc.contributor.institutionHopital Univ Bicetre
dc.contributor.institutionUniv Paris 06
dc.contributor.institutionGrp Hosp Pitie Salpetriere Charles Foix
dc.contributor.institutionUniv Roma La Sapienza
dc.contributor.institutionUniv Belgrade
dc.contributor.institutionFdn Salvatore Maugeri
dc.contributor.institutionLa Sapienza
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Paris 11
dc.contributor.institutionQueens Univ
dc.contributor.institutionUniv Milan
dc.description.affiliationIRCCS, Ctr Cardiol Monzino, Milan, Italy
dc.description.affiliationHopital Univ Bicetre, AP HP, Serv Explorat Fonct Resp, Ctr Reference Hypertens Pulm Severe,DHU TORINO Th, Le Kremlin Bicetre, France
dc.description.affiliationUniv Paris 06, Univ Paris 04, UMR S Neurophysiol Resp Expt & Clin 1158, Paris, France
dc.description.affiliationINSERM, UMR S Neurophysiol Resp Expt & Clin 1158, Paris, France
dc.description.affiliationGrp Hosp Pitie Salpetriere Charles Foix, AP HP, Serv Explorat Fonct Resp Exercice & Dyspnee, Paris, France
dc.description.affiliationUniv Roma La Sapienza, Dipartimento Med Clin, Rome, Italy
dc.description.affiliationUniv Belgrade, Fac Med, Div Cardiol, Belgrade 11000, Serbia
dc.description.affiliationFdn Salvatore Maugeri, IRCCS, Sci Inst Milan, Cardiac Rehabil Unit, Turin, Italy
dc.description.affiliationLa Sapienza, Dipartimento Sci Cardiovasc Resp Anestesiol Nefro, Rome, Italy
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Sch Med UNIFESP EPM, Dept Med, Div Resp, São Paulo, Brazil
dc.description.affiliationUniv Paris 11, Fac Med, Le Kremlin Bicetre, France
dc.description.affiliationINSERM, U999, LabEx LERMIT, Ctr Chirurg Marie Lannelongue, Le Plessis Robinson, France
dc.description.affiliationQueens Univ, Div Resp & Crit Care Med, Fac Hlth Sci, Kingston, ON, Canada
dc.description.affiliationUniv Milan, Dept Clin Sci & Community Hlth, Cardiovasc Sect, I-20122 Milan, Italy
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Sch Med UNIFESP EPM, Dept Med, Div Resp, São Paulo, Brazil
dc.description.sourceWeb of Science

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