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dc.contributor.authorSilveira, Claudio [UNIFESP]
dc.contributor.authorMuccioli, Cristina [UNIFESP]
dc.contributor.authorHolland, Gary N.
dc.contributor.authorJones, Jeffrey L.
dc.contributor.authorYu, Fei
dc.contributor.authorPaulo, Adam de [UNIFESP]
dc.contributor.authorBelfort, Rubens [UNIFESP]
dc.identifier.citationAmerican Journal of Ophthalmology. New York: Elsevier B.V., v. 159, n. 6, p. 1013-1021, 2015.
dc.description.abstractPURPOSE: To investigate ocular involvement (prevalence, incidence, lesion characteristics) following postnatally. acquired infection with an atypical genotype of Toxoplasma gondii during a well-characterized 2001 outbreak in Santa Isabel do Ivai, Brazil, attributed to a contaminated municipal reservoir.DESIGN: Prospective longitudinal cohort study.METHODS: We performed ophthalmic examinations on 290 of 454 individuals with serologic evidence of T gondii infection during the epidemic (positive IgM antibody tests). Prevalence of ophthalmic findings (intraocular inflammatory reactions [including transient, isolated retinal whitening without clinically apparent retinal necrosis] and necrotizing retinochoroiditis) at initial examination (baseline) and incidence of new findings during 10.5 months of follow-up were calculated. Cumulative risks of ophthalmic events were determined (Kaplan-Meier technique). RESULTS: Ocular involvement was present in 33 of 288 IgM individuals (11.5%) at baseline, including 17 with focal retinal whitening only and 13 with necrotizing retinochoroiditis. Incidence of new ocular involvement was estimated to be 1.73 events per 100 person-months (PM); cumulative risk at 10.5 months was 30.1%. Incident necrotizing retinochoroiditis was more common among those with focal retinal whitening at baseline (6.7/100 PM) than among those with no ocular involvement at baseline (1.11/100 PM; hazard ratio 6.07 [1.94-19.01]; P <.0001).CONCLUSIONS: Waterborne infection with an atypical genotype of T gondii is associated with substantial risk of ocular involvement. Lesions may continue to develop during the first year after infection. the increased risk of late necrotizing retinochoroiditis associated with isolated focal retinal whitening at presentation suggests the early presence of parasites in the retina, despite initial lack of observable retinal necrosis. (C) 2015 by Elsevier Inc. All rights reserved.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipResearch to Prevent Blindness (RPB), Inc, New York, New York
dc.description.sponsorshipSkirball Foundation, New York, New York
dc.description.sponsorshipCenters for Disease Control and Prevention, Atlanta, Georgia
dc.description.sponsorshipRPB Physician-Scientist Award
dc.publisherElsevier B.V.
dc.relation.ispartofAmerican Journal of Ophthalmology
dc.rightsAcesso restrito
dc.titleOcular Involvement Following an Epidemic of Toxoplasma gondii Infection in Santa Isabel do Ivai, Brazilen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionClin Silveira
dc.contributor.institutionUniv Calif Los Angeles
dc.contributor.institutionUS Ctr Dis Control & Prevent
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationClin Silveira, Erechim, RS, Brazil
dc.description.affiliationUniv Calif Los Angeles, Jules Stein Eye Inst, David Geffen Sch Med, Ocular Inflammatory Dis Ctr, Los Angeles, CA 90095 USA
dc.description.affiliationUniv Calif Los Angeles, David Geffen Sch Med, Dept Ophthalmol, Los Angeles, CA 90095 USA
dc.description.affiliationUS Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science

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