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dc.contributor.authorDal Molin Netto, Bárbara [UNIFESP]
dc.contributor.authorBettini, Solange Cravo
dc.contributor.authorClemente, Ana Paula Grotti [UNIFESP]
dc.contributor.authorFerreira, Joana Pereira de Carvalho [UNIFESP]
dc.contributor.authorBoritza, Katia
dc.contributor.authorSouza, Sandy de Fatima
dc.contributor.authorVon der Heyde, Maria Emilia
dc.contributor.authorEarthman, Carrie P.
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.date.accessioned2016-01-24T14:40:32Z
dc.date.available2016-01-24T14:40:32Z
dc.date.issued2015-06-01
dc.identifierhttps://dx.doi.org/10.1007/s11695-014-1484-7
dc.identifier.citationObesity Surgery. New York: Springer, v. 25, n. 6, p. 1010-1018, 2015.
dc.identifier.issn0960-8923
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/39117
dc.description.abstractThe low-grade inflammatory state in obesity leads to insulin resistance and endothelial dysfunction, which promote cardiovascular diseases in individuals with obesity. the purpose of this study was to evaluate the early effects of weight loss achieved through bariatric surgery on the inflammatory and prothrombotic states. This study also aimed to identify the role of hyperleptinemia on the prothrombotic state.The sample was composed of 41 extremely obese who underwent Roux-en-Y gastric bypass (RYGB). Anthropometric and clinical data, and biochemical markers of inflammation were collected prior to surgery and 6 months post-RYGB.It was found that plasminogen activator inhibitor-1 (PAI-1) concentrations were higher among extremely obese individuals with hyperleptinemia than in those without hyperleptinemia (p < 0.01).In relation to the baseline, post-surgery body mass index (BMI) was reduced by 12.9 kg/m(2), corresponding to 63.50 % of excess weight loss. Additionally, waist circumference was found to decrease significantly from 126.2 to 101.4 cm. Plasma total cholesterol (p < 0.01), LDL cholesterol (p = 0.02), triglycerides (p < 0.01), and glucose (p = 0.01) were also found to decrease. Pro-inflammatory biomarkers were observed to decrease: PAI-1 by 55.9 +/- 6.0 % (p < 0.01), C-reactive protein (CRP) by 18.8 +/- 3.4 % (p < 0.01), intercellular adhesion molecule-1 (ICAM-1) by 89.9 +/- 5.7 % (p < 0.01), leptin by 27.9 +/- 3.2 % (p < 0.01), and resistin by 69.3 +/- 5.8 % (p < 0.01). Additionally, significant decreases of tumor necrosis factor alpha (TNF-alpha) and leptin/adiponectin ratio were observed. Anti-inflammatory cytokines adiponectin and interleukin-10 (IL-10) were significantly increased (170.7 +/- 82.5 %, p < 0.01; 122.7 +/- 55.1 %, p = 0.02). CRP levels were predictive of ICAM-1 (p = 0.04), and changes in leptin concentrations were associated with decreased PAI-1 levels (p = 0.03).We observed that individuals with obesity that have hyperleptinemia have higher circulating PAI-1 levels, which could indicate increased risk for cardiovascular disease. the biomarkers of inflammation and thrombosis measured in this study decreased after RYGB, suggesting that the surgery may be effective in reducing pro-inflammatory and thrombotic risk in individuals with extreme obesity.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipUNIFESP-EPM
dc.format.extent1010-1018
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofObesity Surgery
dc.rightsAcesso restrito
dc.subjectRoux-en-Y gastric bypassen
dc.subjectObesityen
dc.subjectInflammationen
dc.subjectHyperleptinemiaen
dc.subjectCardiovascularen
dc.titleRoux-en-Y Gastric Bypass Decreases Pro-inflammatory and Thrombotic Biomarkers in Individuals with Extreme Obesityen
dc.typeArtigo
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniv Minnesota Twin Cities
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Postgrad Program Nutr, BR-04020060 São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Postgrad Program Interdisciplinary Hlth Sci, São Paulo, Brazil
dc.description.affiliationUniv Fed Parana UFPR, Bariatr Surg Serv, Hosp Clin, Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Parana UFPR, Biochem Sect, Hosp Clin, Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Parana UFPR, Graduat Nutr, Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Parana UFPR, Dept Nutr, Curitiba, Parana, Brazil
dc.description.affiliationUniv Minnesota Twin Cities, Dept Food Sci & Nutr, St Paul, MN USA
dc.description.affiliationUniv Fed Parana UFPR, Hosp Clin, Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Postgrad Program Nutr, BR-04020060 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Postgrad Program Interdisciplinary Hlth Sci, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2013/04136-4
dc.description.sponsorshipIDCAPES: BEX 2262/14-2
dc.description.sponsorshipIDCAPES: 2566/2011
dc.identifier.doi10.1007/s11695-014-1484-7
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000354216500009


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