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dc.contributor.authorCorreia, Ana Carolina de C.
dc.contributor.authorFerreira, Tamyris F.
dc.contributor.authorMartins, Italo Rossi R.
dc.contributor.authorMacedo, Ciberio L.
dc.contributor.authorMonteiro, Fabio de S.
dc.contributor.authorCosta, Vicente Carlos O.
dc.contributor.authorTavares, Josean F.
dc.contributor.authorSilva, Marcelo S.
dc.contributor.authorParedes-Gamero, Edgar J. [UNIFESP]
dc.contributor.authorBuri, Marcus V. [UNIFESP]
dc.contributor.authorRigoni, Vera L. S. [UNIFESP]
dc.contributor.authorNouailhetas, Viviane L. A. [UNIFESP]
dc.contributor.authorDa Silva, Bagnolia A.
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 29, n. 10, p. 980-984, 2015.
dc.description.abstractXylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae) is popularly known in the northeast of Brazil as pimenteira da terra', and an essential oil (XL-OE) was extracted from its leaves. Since Xylopia species are cited in folk medicine and diterpenes from X. langsdorfiana have spasmolytic activity, this study aimed to investigate a possible spasmolytic action of XL-OE on smooth muscle models. XL-OE (243 and 729g/mL) showed low pharmacologic efficacy on guinea pig trachea and rat aorta and uterus. However, in guinea pig ileum, XL-OE (27-729g/mL) inhibited carbachol or histamine-induced phasic contractions (1M) in a significant and concentration-dependent manner. in addition, XL-OE (81g/mL) reduced fluorescence intensity in ileal myocytes stimulated by histamine, indicating a decrease in cytosolic calcium concentration, which could explain the spasmolytic activity. Thus, XL-OE proved to be a promising natural product to be used in gastrointestinal diseases acting by modulating the cytosolic calcium concentration.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.rightsAcesso restrito
dc.subjectsmooth muscleen
dc.subjectessential oilen
dc.titleEssential oil from the leaves of Xylopia langsdorfiana (Annonaceae) as a possible spasmolytic agenten
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationFed Univ Paraiba UFPB, Ctr Hlth Sci CCS, BR-58051970 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationDept Pharmaceut Sci DCF CCS UFPB, BR-58051970 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biochem, São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biophys, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biophys, São Paulo, Brazil
dc.description.sourceWeb of Science

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