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Essential oil from the leaves of Xylopia langsdorfiana (Annonaceae) as a possible spasmolytic agent

dc.contributor.authorCorreia, Ana Carolina de C.
dc.contributor.authorFerreira, Tamyris F.
dc.contributor.authorMartins, Italo Rossi R.
dc.contributor.authorMacedo, Ciberio L.
dc.contributor.authorMonteiro, Fabio de S.
dc.contributor.authorCosta, Vicente Carlos O.
dc.contributor.authorTavares, Josean F.
dc.contributor.authorSilva, Marcelo S.
dc.contributor.authorParedes-Gamero, Edgar J. [UNIFESP]
dc.contributor.authorBuri, Marcus V. [UNIFESP]
dc.contributor.authorRigoni, Vera L. S. [UNIFESP]
dc.contributor.authorNouailhetas, Viviane L. A. [UNIFESP]
dc.contributor.authorDa Silva, Bagnolia A.
dc.date.accessioned2016-01-24T14:40:31Z
dc.date.available2016-01-24T14:40:31Z
dc.date.issued2015-05-19
dc.identifierhttp://dx.doi.org/10.1080/14786419.2014.964706
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 29, n. 10, p. 980-984, 2015.
dc.identifier.issn1478-6419
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39109
dc.description.abstractXylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae) is popularly known in the northeast of Brazil as pimenteira da terra', and an essential oil (XL-OE) was extracted from its leaves. Since Xylopia species are cited in folk medicine and diterpenes from X. langsdorfiana have spasmolytic activity, this study aimed to investigate a possible spasmolytic action of XL-OE on smooth muscle models. XL-OE (243 and 729g/mL) showed low pharmacologic efficacy on guinea pig trachea and rat aorta and uterus. However, in guinea pig ileum, XL-OE (27-729g/mL) inhibited carbachol or histamine-induced phasic contractions (1M) in a significant and concentration-dependent manner. in addition, XL-OE (81g/mL) reduced fluorescence intensity in ileal myocytes stimulated by histamine, indicating a decrease in cytosolic calcium concentration, which could explain the spasmolytic activity. Thus, XL-OE proved to be a promising natural product to be used in gastrointestinal diseases acting by modulating the cytosolic calcium concentration.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent980-984
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.rightsAcesso restrito
dc.subjectAnnonaceaeen
dc.subjectsmooth muscleen
dc.subjectantispasmodicen
dc.subjectcalciumen
dc.subjectessential oilen
dc.titleEssential oil from the leaves of Xylopia langsdorfiana (Annonaceae) as a possible spasmolytic agenten
dc.typeArtigo
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationFed Univ Paraiba UFPB, Ctr Hlth Sci CCS, BR-58051970 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationDept Pharmaceut Sci DCF CCS UFPB, BR-58051970 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biochem, São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biophys, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biophys, São Paulo, Brazil
dc.identifier.doi10.1080/14786419.2014.964706
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000353422200017


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