Essential oil from the leaves of Xylopia langsdorfiana (Annonaceae) as a possible spasmolytic agent

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2015-05-19
Autores
Correia, Ana Carolina de C.
Ferreira, Tamyris F.
Martins, Italo Rossi R.
Macedo, Ciberio L.
Monteiro, Fabio de S.
Costa, Vicente Carlos O.
Tavares, Josean F.
Silva, Marcelo S.
Paredes-Gamero, Edgar J. [UNIFESP]
Buri, Marcus V. [UNIFESP]
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Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae) is popularly known in the northeast of Brazil as pimenteira da terra', and an essential oil (XL-OE) was extracted from its leaves. Since Xylopia species are cited in folk medicine and diterpenes from X. langsdorfiana have spasmolytic activity, this study aimed to investigate a possible spasmolytic action of XL-OE on smooth muscle models. XL-OE (243 and 729g/mL) showed low pharmacologic efficacy on guinea pig trachea and rat aorta and uterus. However, in guinea pig ileum, XL-OE (27-729g/mL) inhibited carbachol or histamine-induced phasic contractions (1M) in a significant and concentration-dependent manner. in addition, XL-OE (81g/mL) reduced fluorescence intensity in ileal myocytes stimulated by histamine, indicating a decrease in cytosolic calcium concentration, which could explain the spasmolytic activity. Thus, XL-OE proved to be a promising natural product to be used in gastrointestinal diseases acting by modulating the cytosolic calcium concentration.
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Natural Product Research. Abingdon: Taylor & Francis Ltd, v. 29, n. 10, p. 980-984, 2015.
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