Telomere length as a marker of sleep loss and sleep disturbances: a potential link between sleep and cellular senescence
Tempaku, Priscila F. [UNIFESP]
Mazzotti, Diego R. [UNIFESP]
Tufik, Sergio [UNIFESP]
Is part ofSleep Medicine
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The identification of biological markers that allow the early diagnosis, or even the prevention of age-related diseases, is an important goal that is being actively pursued in the research community. Sleep is one of the physiological processes that is most affected by aging, and there is a strong relationship between age-related sleep alterations and diseases. Changes in cellular senescence and the linked changes in telomere length might be potential markers of age-related sleep changes. in this review, we present some of the most recent evidence showing that telomere length has been associated with sleep loss and sleep disturbances in cross-sectional and case-control studies. We also present insights into the cellular senescence mechanisms relating to changes in telomere length, and we suggest that this field lacks basic and clinical research studies, especially long-term longitudinal studies, which may bring opportunities to sleep researchers to investigate this relationship in more depth. (C) 2015 Elsevier B.V. All rights reserved.
CitationSleep Medicine. Amsterdam: Elsevier B.V., v. 16, n. 5, p. 559-563, 2015.
SponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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