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dc.contributor.authorBarros, Vanessa Novaes [UNIFESP]
dc.contributor.authorMundim, Mayara [UNIFESP]
dc.contributor.authorGalindo, Layla Testa [UNIFESP]
dc.contributor.authorBittencourt, Simone [UNIFESP]
dc.contributor.authorPorcionatto, Marimelia [UNIFESP]
dc.contributor.authorMello, Luiz Eugenio Araujo de Moraes [UNIFESP]
dc.date.accessioned2016-01-24T14:40:14Z
dc.date.available2016-01-24T14:40:14Z
dc.date.issued2015-03-12
dc.identifierhttp://journal.frontiersin.org/article/10.3389/fncel.2015.00072/abstract
dc.identifier.citationFrontiers in Cellular Neuroscience. Lausanne: Frontiers Research Foundation, v. 9, 8 p., 2015.
dc.identifier.issn1662-5102
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38882
dc.description.abstractIntense activation of neurons triggers the appearance of immediate expression genes, including c-Fos. This gene is related to various signal cascades involved in biochemical processes such as neuronal plasticity, cell growth and mitosis. Here we investigate the expression pattern and the refractory period of c-Fos in rats and monkey's brains after stimulation with pentylenetetrazol. Rats and monkeys were sacrificed at various times after PTZ-induced seizure. Here we show that rats and monkeys already showed c-Fos expression at 0.5 h after seizure. Yet, the pattern of protein expression was longer in monkeys than rats, and also was not uniform (relative intensity) across different brain regions in monkeys as opposed to rats. in addition monkeys had a regional brain variation with regard to the temporal profile of c-Fos expression, which was not seen in rats. the refractory period after a second PTZ stimulation was also markedly different between rats and monkeys with the latter even showing a summatory effect on c-Fos expression after a second stimulation. However, assessment of c-Fos mRNA in rats indicated a post-transcriptional control mechanism underlying the duration of the refractory period. the difference in the protein expression pattern in rodents and primates characterizes a functional aspect of brain biochemistry that differs between these mammalian orders and may contribute for the more developed primate cognitive complexity as compared to rodents given c-Fos involvement in cognitive and learning tasks.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent8
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofFrontiers in Cellular Neuroscience
dc.rightsAcesso aberto
dc.subjectc-Fos expressionen
dc.subjectbrain plasticityen
dc.subjectmarmosetsen
dc.subjectphylogenyen
dc.subjectneuronal activationen
dc.titleThe pattern of c-Fos expression and its refractory period in the brain of rats and monkeysen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04039032 São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biochem, BR-04039032 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04039032 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biochem, BR-04039032 São Paulo, SP, Brazil
dc.identifier.fileWOS000352401300001.pdf
dc.identifier.doi10.3389/fnce1.2015.00072
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000352401300001


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