Effect of APOE and CHRNA7 Genotypes on the Cognitive Response to Cholinesterase Inhibitor Treatment at Different Stages of Alzheimer's Disease

Effect of APOE and CHRNA7 Genotypes on the Cognitive Response to Cholinesterase Inhibitor Treatment at Different Stages of Alzheimer's Disease

Author Sampaio Braga, Ianna Lacerda Autor UNIFESP Google Scholar
Silva, Patricia Natalia Autor UNIFESP Google Scholar
Furuya, Tatiane Katsue Autor UNIFESP Google Scholar
Santos, Leonardo Caires Autor UNIFESP Google Scholar
Pires, Belisa Caldana Autor UNIFESP Google Scholar
Mazzotti, Diego Robles Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Autor UNIFESP Google Scholar
Cendoroglo, Maysa Seabra Autor UNIFESP Google Scholar
Smith, Marilia Cardoso Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The loss of cholinergic transmission is considered to be an important cause of Alzheimer's disease (AD). Treatment with acetyl cholinesterase inhibitors (ChEIs) shows benefits; however, great heterogeneity has been observed in patient responses. We evaluated apolipoprotein E (APOE) and 7 nicotinic receptor (CHRNA7) single-nucleotide polymorphisms (SNPs) and associated these SNPs with pharmacological responses to ChEIs in a Brazilian population with AD. We studied 177 outpatients using ChEIs, and they were classified as responders and nonresponders according to variation in Mini-Mental State Examination (MMSE) status. the analysis of APOE genotypes showed that patients with the 4 allele had a worse response than those without the 4 allele. We observed an association between the CHRNA7 T allele and a better response to treatment with ChEIs in patients with mild AD (MMSE 20). the SNP rs6494223 of CHRNA7 as well as APOE4 could be useful for understanding the response to ChEI treatment in patients with AD.
Keywords pharmacogenomics
Alzheimer's disease
cholinesterase inhibitor
CHRNA7
APOE
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2015-03-01
Published in American Journal of Alzheimers Disease and Other Dementias. Thousand Oaks: Sage Publications Inc, v. 30, n. 2, p. 139-144, 2015.
ISSN 1533-3175 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Inc
Extent 139-144
Origin http://dx.doi.org/10.1177/1533317514539540
Access rights Closed access
Type Article
Web of Science ID WOS:000351707000004
URI http://repositorio.unifesp.br/handle/11600/38863

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