Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?

Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?

Author Carvalho-Ferreira, Joana Pereira de Autor UNIFESP Google Scholar
Masquio, Deborah Cristina Landi Autor UNIFESP Google Scholar
Campos, Raquel Munhoz da Silveira Autor UNIFESP Google Scholar
Dal Molin Netto, Bárbara Autor UNIFESP Google Scholar
Corgosinho, Flavia Campos Autor UNIFESP Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Tock, Lian Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Finlayson, Graham Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Weight Sci
Univ Leeds
Abstract Several studies have sought to clarify the association between adolescent obesity and psychological distress. Recently, a biological link between leptin resistance and depression has been proposed. the aim of the present study was to examine changes in leptin concentrations as a potential predictor of reduced depression symptoms in obese adolescents during long-term interdisciplinary weight loss therapy. Seventy-five obese adolescents (age: 16.28 +/- 2.37 years; BMI: 35.65 +/- 4.64 kg/m(2)) engaged in a long-term interdisciplinary therapy for weight loss. They were evaluated at baseline and after 1 year of treatment for body composition, serum analyses and depression symptomatology. After therapy, body mass BMI, fat mass (% and kg), waist circumference, visceral, subcutaneous and visceral/subcutaneous fat and depression symptoms decreased and lean mass (%) increased significantly. There was an improvement in inflammatory profiles with a significant reduction in leptin and increase in adiponectin. Regression analyses showed that decreased leptin predicted amelioration in depression symptoms independent of age, gender and changes in visceral fat, body mass, fat mass (%) and leptin/adiponectin ratio. These associations appear stronger in girls than boys. the attenuation of hyperleptinemia appears to play an important role in the association between weight loss and depression, particularly in obese girls. (C) 2015 Elsevier Inc. All rights reserved.
Keywords Depression
Leptin resistance
Language English
Sponsor AFIP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2011/50356-0
FAPESP: 2011/50414-0
FAPESP: 2013/041364
CAPES: BEX 14189/13-5
Date 2015-03-01
Published in Peptides. New York: Elsevier B.V., v. 65, p. 20-28, 2015.
ISSN 0196-9781 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 20-28
Access rights Closed access
Type Article
Web of Science ID WOS:000352808900004

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