Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency

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dc.contributor.author Santos-Miranda, Artur
dc.contributor.author Cruz, Jader Santos
dc.contributor.author Roman-Campos, Danilo [UNIFESP]
dc.date.accessioned 2016-01-24T14:40:08Z
dc.date.available 2016-01-24T14:40:08Z
dc.date.issued 2015-03-01
dc.identifier http://dx.doi.org/10.5935/abc.20150010
dc.identifier.citation Arquivos Brasileiros de Cardiologia. Rio de Janeiro: Arquivos Brasileiros Cardiologia, v. 104, n. 3, p. 242-245, 2015.
dc.identifier.issn 0066-782X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38806
dc.description.abstract In modern society, thiamine deficiency (TD) remains an important medical condition linked to altered cardiac function. There have been contradictory reports about the impact of TD on heart physiology, especially in the context of cardiac excitability. in order to address this particular question, we used a TD rat model and patch-clamp technique to investigate the electrical properties of isolated cardiomyocytes from epicardium and endocardium. Neither cell type showed substantial differences on the action potential waveform and transient outward potassium current. Based on our results we can conclude that TD does not induce major electrical remodeling in isolated cardiac myocytes in either endocardium or epicardium cells. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.format.extent 242-245
dc.language.iso eng
dc.publisher Arquivos Brasileiros Cardiologia
dc.relation.ispartof Arquivos Brasileiros de Cardiologia
dc.rights Acesso aberto
dc.subject Myocytes, Cardiac en
dc.subject Electric Stimulation en
dc.subject Thiamine Deficiency/physiopathology en
dc.subject Action Potentials en
dc.subject Rats, Heart Failure en
dc.title Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency en
dc.title.alternative Propriedades Elétricas de Cardiomiócitos Isolados em um Modelo Animal em Ratos com Deficiência de Tiamina pt
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal de Minas Gerais (UFMG)
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliation Univ Fed Minas Gerais, Minas Gerais, MG, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.identifier.file S0066-782X2015000300010.pdf
dc.identifier.scielo S0066-782X2015000300010
dc.identifier.doi 10.5935/abc.20150010
dc.description.source Web of Science
dc.identifier.wos WOS:000353056200014


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