Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency

Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency

Alternative title Propriedades Elétricas de Cardiomiócitos Isolados em um Modelo Animal em Ratos com Deficiência de Tiamina
Author Santos-Miranda, Artur Google Scholar
Cruz, Jader Santos Google Scholar
Roman-Campos, Danilo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Minas Gerais (UFMG)
Abstract In modern society, thiamine deficiency (TD) remains an important medical condition linked to altered cardiac function. There have been contradictory reports about the impact of TD on heart physiology, especially in the context of cardiac excitability. in order to address this particular question, we used a TD rat model and patch-clamp technique to investigate the electrical properties of isolated cardiomyocytes from epicardium and endocardium. Neither cell type showed substantial differences on the action potential waveform and transient outward potassium current. Based on our results we can conclude that TD does not induce major electrical remodeling in isolated cardiac myocytes in either endocardium or epicardium cells.
Keywords Myocytes, Cardiac
Electric Stimulation
Thiamine Deficiency/physiopathology
Action Potentials
Rats, Heart Failure
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Date 2015-03-01
Published in Arquivos Brasileiros de Cardiologia. Rio de Janeiro: Arquivos Brasileiros Cardiologia, v. 104, n. 3, p. 242-245, 2015.
ISSN 0066-782X (Sherpa/Romeo, impact factor)
Publisher Arquivos Brasileiros Cardiologia
Extent 242-245
Origin http://dx.doi.org/10.5935/abc.20150010
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000353056200014
SciELO ID S0066-782X2015000300010 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/38806

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