Effect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomy

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Oliveira, Caio Marcio Barros de [UNIFESP]
Sakata, Rioko Kimiko [UNIFESP]
Slullitel, Alexandre
Salomão, Reinaldo [UNIFESP]
Lanchote, Vera Lucia
Issy, Adriana Machado [UNIFESP]
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Background and objectives: Interleukin-6 (IL-6) is a predictor of trauma severity. the purpose of this study was to evaluate the effect of intravenous lidocaine on pain severity and plasma IL-6 after hysterectomy.Method: A prospective, randomized, comparative, double-blind study with 40 patients, aged 18-60 years. G1 received lidocaine (2 mg.kg(-1).h(-1)) or G2 received 0.9% saline solution during the operation. Anesthesia was induced with O-2/isoflurane. Pain severity (T0: awake and 6, 12, 18 and 24 hours), first analgesic request, and dose of morphine in 24 hours were evaluated. IL-6 was measured before starting surgery (TO), five hours after the start (T5), and 24 hours after the end of surgery (124).Results: There was no difference in pain severity between groups. There was a decrease in pain severity between TO and other measurement times in G1. Time to first supplementation was greater in G2 (76.0 104.4 min) than in G1 (26.7 23.3 min). There was no difference in supplemental dose of morphine between G1 (23.5 12.6 mg) and G2 (18.7 +/- 11.3 mg). There were increased concentrations of IL-6 in both groups from TO to T5 and T24. There was no difference in IL-6 dosage between groups. Lidocaine concentration was 856.5 +/- 364.1 ng.mL(-1) in T5 and 30.1 +/- 14.2 ng.mL(-1) in T24.Conclusion: Intravenous lidocaine (2 mg.kg(-1).h(-1)) did not reduce pain severity and plasma levels of IL-6 in patients undergoing abdominal hysterectomy. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.
Revista Brasileira de Anestesiologia. New York: Elsevier B.V., v. 65, n. 2, p. 92-98, 2015.