Molecular Insights into the Possible Role of Kir4.1 and Kir5.1 in Thyroid Hormone Biosynthesis

Molecular Insights into the Possible Role of Kir4.1 and Kir5.1 in Thyroid Hormone Biosynthesis

Author Ramos, Helton Estrela Google Scholar
Dias da Silva, Magnus Regios Autor UNIFESP Google Scholar
Carre, Aurore Google Scholar
Silva, Joaquim Custodio Google Scholar
Paninka, Rolf Matias Autor UNIFESP Google Scholar
Oliveira, Taise Lima Google Scholar
Tron, Elodie Google Scholar
Castanet, Mireille Google Scholar
Polak, Michel Google Scholar
Institution Univ Paris 05
Hop Necker Enfants Malad
Univ Hosp Rouen
Universidade Federal da Bahia (UFBA)
Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction: Thyroid morphogenesis is a complex process. Inwardly rectifying potassium (Kir) genes play a role in hormone release, cell excitability, pH and K+ homeostasis in many tissues. Objectives: To investi gate the thyroid developmental expression of three members, Kir4.1, Kir4.2 and Kir5.1, in mice. To postulate the K+ channel role in thyroid hormone secretion. Material and Methods: Quantitative RTPCR analysis of Kir4.1, Kir4.2 and Kir5.1 in mice of different stages (E13.5-E18.5). Results: mRNA for Kir4.1, Kir4.2 and Kir5.1 were identified and increased with age in mice. Both Kir4.1 and Kir4.2 genes are better expressed after E16.5. Kir4.2 greatly increases from E13.5 to E16.5 (p >= 0.05). Conclusion: Quantitative PCR shows that the mouse thyroid presents increased expression for Kir channels during development. the role of Kir in thyroid morphogenesis and differ entiation might be understood in future studies. We speculate that thyroglobulin trafficking might be modulated by Kir4.1/5.1. (C) 2015 S. Karger AG, Basel
Keywords Potassium channel
Thyroid
Congenital hypothyroidism
Language English
Sponsor Electricite de France
European Society for Paediatric Endocrinology (ESPE) Research Unit
Fondation Grace de Monaco
French Ministry, Fapesb (Fundacao de Amparo a Pesquisa no Estado da Bahia)
SFE (Societe francaise d'endocrinologie)
Merck Serono grant
Sandoz educational grant
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number Electricite de France: RB 200605
Date 2015-01-01
Published in Hormone Research in Paediatrics. Basel: Karger, v. 83, n. 2, p. 141-147, 2015.
ISSN 1663-2818 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 141-147
Origin http://dx.doi.org/10.1159/000369251
Access rights Closed access
Type Article
Web of Science ID WOS:000351594900011
URI http://repositorio.unifesp.br/handle/11600/38614

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