Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism

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2015-01-01
Autores
Hughes, Ashley J.
Rudd, Timothy R.
Wright, Gareth S. A.
Fernig, David G.
Siligardi, Giuliano
Yates, Edwin A. [UNIFESP]
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Presented herein is a novel method for the detection of tryptophan-ligand interactions utilising magnetic circular dichroism. Two examples are presented, one a small molecule and another, a large polysaccharide, heparan sulfate. These data are also the first reported example of a Trp-glycosaminoglycan interaction shown by magnetic circular dichroism.
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Analytical Methods. Cambridge: Royal Soc Chemistry, v. 7, n. 5, p. 1667-1671, 2015.
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