Effect of photodynamic therapy on the extracellular matrix and associated components

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dc.contributor.author Pazos, Marcelo de Castro [UNIFESP]
dc.contributor.author Nader, Helena Bonciani [UNIFESP]
dc.date.accessioned 2015-06-14T13:37:02Z
dc.date.available 2015-06-14T13:37:02Z
dc.date.issued 2007-08-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2006005000142
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 8, p. 1025-1035, 2007.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/3852
dc.description.abstract In many countries, photodynamic therapy (PDT) has been recognized as a standard treatment for malignant conditions (for example, esophageal and lung cancers) and non-malignant ones such as age-related macular degeneration and actinic keratoses. The administration of a non-toxic photosensitizer, its selective retention in highly proliferating cells and the later activation of this molecule by light to form reactive oxygen species that cause cell death is the principle of PDT. Three important mechanisms are responsible for the PDT effectiveness: a) direct tumor cell kill; b) damage of the tumor vasculature; c) post-treatment immunological response associated with the leukocyte stimulation and release of many inflammatory mediators like cytokines, growth factors, components of the complement system, acute phase proteins, and other immunoregulators. Due to the potential applications of this therapy, many studies have been reported regarding the effect of the treatment on cell survival/death, cell proliferation, matrix assembly, proteases and inhibitors, among others. Studies have demonstrated that PDT alters the extracellular matrix profoundly. For example, PDT induces collagen matrix changes, including cross-linking. The extracellular matrix is vital for tissue organization in multicellular organisms. In cooperation with growth factors and cytokines, it provides cells with key signals in a variety of physiological and pathological processes, for example, adhesion/migration and cell proliferation/differentiation/death. Thus, the focus of the present paper is related to the effects of PDT observed on the extracellular matrix and on the molecules associated with it, such as, adhesion molecules, matrix metalloproteinases, growth factors, and immunological mediators. en
dc.format.extent 1025-1035
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Photodynamic therapy en
dc.subject Extracellular matrix en
dc.subject Adhesion en
dc.subject Chemical mediators en
dc.subject Matrix metalloproteinases en
dc.title Effect of photodynamic therapy on the extracellular matrix and associated components en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Bioquímica
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Bioquímica
dc.identifier.file S0100-879X2007000800002.pdf
dc.identifier.scielo S0100-879X2007000800002
dc.identifier.doi 10.1590/S0100-879X2006005000142
dc.description.source SciELO
dc.identifier.wos WOS:000248413400002


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