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dc.contributor.authorGaspar, Alexandra Passos [UNIFESP]
dc.contributor.authorBrandao, Cynthia Maria Alvares [UNIFESP]
dc.contributor.authorLazaretti-Castro, Marise [UNIFESP]
dc.date.accessioned2016-01-24T14:38:13Z
dc.date.available2016-01-24T14:38:13Z
dc.date.issued2014-12-01
dc.identifierhttp://dx.doi.org/10.1210/jc.2014-2165
dc.identifier.citationJournal of Clinical Endocrinology & Metabolism. Washington: Endocrine Soc, v. 99, n. 12, p. 4649-4655, 2014.
dc.identifier.issn0021-972X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38480
dc.description.abstractContext: Bone loss is a constant finding in patients with spinal cord injury (SCI).Objective: We sought to evaluate potential modifiable factors that could lead to bone loss in complete motor paraplegia by examining gonadal axis hormones, vitamin D status, and bone markers.Design: This is a cross sectional.Setting: It includes SCI Outpatient.Patients and other Participants: Twenty-nine chronic male patients with SCI were compared with 17 age-matched, able-bodied men.Main Outcome Measure: the bone mineral density (BMD) of lower limbs and lumbar spine were measured using dual x-ray absorptiometry. Parathormone, 25-hydroxyvitamin D [ 25(OH) D], collagen type I C-terminal telopeptide (CTX), and sexual hormone were measured.Results: Patients with SCI had lower BMD at the inferior limbs sites. CTX showed an inverse relationship with the time since injury. Patients had lower free T levels (SCI, 12.00 +/- 2.91 vs controls, 19.51 +/- 5.72; P <= .001), and the majority (72%) had normal/low levels of gonadotropins. Low T, however, was not related to low bone mass in patients with SCI. in the controls, the 25(OH) D level was positively correlated with the T and with the lumbar spine BMD, but these correlations were not observed in the SCI.Conclusions: Impairment of testicular function after SCI was indicated by the low levels of T and the loss of correlation between T and 25(OH) D levels; this correlation was present in the able-bodied controls. Inappropriate levels of gonadotropins were identified in most patients, featuring a hypogonadotropic hypogonadism and suggesting a disruption of the pituitary-gonadal axis. T concentrations might not be an effective target for bone loss therapy.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent4649-4655
dc.language.isoeng
dc.publisherEndocrine Soc
dc.relation.ispartofJournal of Clinical Endocrinology & Metabolism
dc.rightsAcesso aberto
dc.titleBone Mass and Hormone Analysis in Patients With Spinal Cord Injury: Evidence for a Gonadal Axis Disruptionen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionAssoc Assistencia Crianca Deficiente
dc.description.affiliationUniversidade Federal de São Paulo, Div Endocrinol, BR-04021001 São Paulo, Brazil
dc.description.affiliationAssoc Assistencia Crianca Deficiente, BR-04027000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Endocrinol, BR-04021001 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2009-05819-2
dc.identifier.doi10.1210/jc.2014-2165
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000346743300037


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