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dc.contributor.authorOta, Vanessa Kiyomi [UNIFESP]
dc.contributor.authorNoto, Cristiano [UNIFESP]
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorSantoro, Marcos Leite [UNIFESP]
dc.contributor.authorOrtiz, Bruno Bertolucci [UNIFESP]
dc.contributor.authorAndrade, Elvis Henrique [UNIFESP]
dc.contributor.authorTasso, Brazilio Carvalho
dc.contributor.authorNery Spindola, Leticia Maria [UNIFESP]
dc.contributor.authorSilva, Patricia Natalia [UNIFESP]
dc.contributor.authorAbilio, Vanessa Costhek [UNIFESP]
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.authorSato, Joao Ricardo [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.contributor.authorCordeiro, Quirino [UNIFESP]
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorBelangero, Sintia Iole [UNIFESP]
dc.date.accessioned2016-01-24T14:37:49Z
dc.date.available2016-01-24T14:37:49Z
dc.date.issued2014-09-01
dc.identifierhttp://dx.doi.org/10.1016/j.jpsychires.2014.05.012
dc.identifier.citationJournal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 56, p. 130-136, 2014.
dc.identifier.issn0022-3956
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38168
dc.description.abstractA study of the gene expression levels in the blood of individuals with schizophrenia in the beginning of the disease, such as first-episode psychosis (FEP), is useful to detect gene expression changes in this disorder in response to treatment. Although a large number of genetic studies on schizophrenia have been conducted, little is known about the effects of antipsychotic treatment on gene expression. the aim of the present study was to examine differences in the gene expression in the blood of antipsychotic-naive FEP patients before and after risperidone treatment (N = 44) and also to verify the correlation with treatment response. in addition, we determined the correlations between differentially expressed genes and clinical variables. the expression of 40 neurotransmitter and neurodevelopment-associated genes was assessed using the RT2 Profiler (TM) PCR Array. the results indicated that the GABRR2 gene was downregulated after risperidone treatment, but no genes were associated with response to treatment and clinical variables after Bonferroni correction. GABRR2 downregulation after treatment can both suggest an effect of risperidone treatment or processes related to disease progression, either not necessarily associated with the improvement of symptoms. Despite this change was observed in blood, this decrease in GABRR2 mRNA levels might be an effect of changes in GABA concentrations or other systems interplay consequently to D2 blockage induced by risperidone, for example. Thus, it is important to consider that antipsychotics or the progression of psychotic disorders might interfere with gene expression. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent130-136
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Psychiatric Research
dc.rightsAcesso restrito
dc.subjectGene expressionen
dc.subjectGABA Rho-2en
dc.subjectRisperidoneen
dc.subjectSchizophreniaen
dc.titleEvaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: A follow-up study in antipsychotic-naive patients with first-episode psychosisen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionISCMSP
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Morphol & Genet, Div Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, LiNC Interdisciplinary Lab Clin Neurosci, BR-05039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationISCMSP, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Math Computat & Cognit, Santo Andre, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Morphol & Genet, Div Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, LiNC Interdisciplinary Lab Clin Neurosci, BR-05039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Pharmacol, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2010/08968-6
dc.description.sponsorshipIDFAPESP: 2010/19176-3
dc.description.sponsorshipIDFAPESP: 2011/50740-5
dc.description.sponsorshipIDFAPESP: 2013/10498-6
dc.identifier.doi10.1016/j.jpsychires.2014.05.012
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000340318600017


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