Evaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: A follow-up study in antipsychotic-naive patients with first-episode psychosis

Evaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: A follow-up study in antipsychotic-naive patients with first-episode psychosis

Author Ota, Vanessa Kiyomi Autor UNIFESP Google Scholar
Noto, Cristiano Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Santoro, Marcos Leite Autor UNIFESP Google Scholar
Ortiz, Bruno Bertolucci Autor UNIFESP Google Scholar
Andrade, Elvis Henrique Autor UNIFESP Google Scholar
Tasso, Brazilio Carvalho Google Scholar
Nery Spindola, Leticia Maria Autor UNIFESP Google Scholar
Silva, Patricia Natalia Autor UNIFESP Google Scholar
Abilio, Vanessa Costhek Autor UNIFESP Google Scholar
Cardoso Smith, Marilia de Arruda Autor UNIFESP Google Scholar
Sato, Joao Ricardo Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Cordeiro, Quirino Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Belangero, Sintia Iole Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC (UFABC)
Abstract A study of the gene expression levels in the blood of individuals with schizophrenia in the beginning of the disease, such as first-episode psychosis (FEP), is useful to detect gene expression changes in this disorder in response to treatment. Although a large number of genetic studies on schizophrenia have been conducted, little is known about the effects of antipsychotic treatment on gene expression. the aim of the present study was to examine differences in the gene expression in the blood of antipsychotic-naive FEP patients before and after risperidone treatment (N = 44) and also to verify the correlation with treatment response. in addition, we determined the correlations between differentially expressed genes and clinical variables. the expression of 40 neurotransmitter and neurodevelopment-associated genes was assessed using the RT2 Profiler (TM) PCR Array. the results indicated that the GABRR2 gene was downregulated after risperidone treatment, but no genes were associated with response to treatment and clinical variables after Bonferroni correction. GABRR2 downregulation after treatment can both suggest an effect of risperidone treatment or processes related to disease progression, either not necessarily associated with the improvement of symptoms. Despite this change was observed in blood, this decrease in GABRR2 mRNA levels might be an effect of changes in GABA concentrations or other systems interplay consequently to D2 blockage induced by risperidone, for example. Thus, it is important to consider that antipsychotics or the progression of psychotic disorders might interfere with gene expression. (C) 2014 Elsevier B.V. All rights reserved.
Keywords Gene expression
GABA Rho-2
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2010/08968-6
FAPESP: 2010/19176-3
FAPESP: 2011/50740-5
FAPESP: 2013/10498-6
Date 2014-09-01
Published in Journal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 56, p. 130-136, 2014.
ISSN 0022-3956 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 130-136
Origin http://dx.doi.org/10.1016/j.jpsychires.2014.05.012
Access rights Closed access
Type Article
Web of Science ID WOS:000340318600017
URI http://repositorio.unifesp.br/handle/11600/38168

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