Antileishmanial activity evaluation of adunchalcone, a new prenylated dihydrochalcone from Piper aduncum L.

Nenhuma Miniatura disponível
Data
2014-09-01
Autores
Dal Picolo, Camilla R. [UNIFESP]
Bezerra, Mariana P. [UNIFESP]
Gomes, Kaio S. [UNIFESP]
Passero, Luiz Felipe D.
Laurenti, Marcia D.
Martins, Euder Glendes A.
Sartorelli, Patricia [UNIFESP]
Lago, Joao Henrique G. [UNIFESP]
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Bioactivity-guided fractionation of EtOH extract from the leaves of Piper aduncum L. (Piperaceae) afforded a new dihydrochalcone, named adunchalcone. Its structure was elucidated on the basis of their spectroscopic data, primarily NMR and MS. Adunchalcone was evaluated against promastigote forms of Leishmania (L.) amazonensis, L. (V.) braziliensis, L. (V.) shawl, and L. (L.) chagasi and displayed 50% effective concentrations (EC50) of 11.03, 26.70, and 11.26 mu M, as well as selective indexes of 4.86, 2.01, 4.76 and 0.50, respectively. This compound was also tested against intracellular forms of L. (L.) amazonensis, displaying weak activity, in comparison to reference drug amphotericin B. However, despite reduced effect of adunchalcone against amastigotes of L. (L.) amazonensis, this work opens the perspective to use this particular molecule as a scaffold for the design of novel and selective drug candidates for neglected diseases, mainly leishmaniasis. (c) 2014 Elsevier B.V. All rights reserved.
Descrição
Citação
Fitoterapia. Amsterdam: Elsevier B.V., v. 97, p. 28-33, 2014.