Cortical thinning of the right anterior cingulate cortex in spider phobia: A magnetic resonance imaging and spectroscopy study

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dc.contributor.author Linares, I. M. P.
dc.contributor.author Jackowski, A. P. [UNIFESP]
dc.contributor.author Trzesniak, C. M. F.
dc.contributor.author Arrais, K. C.
dc.contributor.author Chagas, M. H. N.
dc.contributor.author Sato, J. R.
dc.contributor.author Santos, A. C.
dc.contributor.author Hallak, J. E. C.
dc.contributor.author Zuardi, A. W.
dc.contributor.author Nardi, A. E.
dc.contributor.author Coimbra, N. C.
dc.contributor.author Crippa, J. A. S.
dc.date.accessioned 2016-01-24T14:37:43Z
dc.date.available 2016-01-24T14:37:43Z
dc.date.issued 2014-08-12
dc.identifier http://dx.doi.org/10.1016/j.brainres.2014.05.040
dc.identifier.citation Brain Research. Amsterdam: Elsevier B.V., v. 1576, p. 35-42, 2014.
dc.identifier.issn 0006-8993
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38088
dc.description.abstract There a lack of consistent neuroimaging data on specific phobia (SP) and a need to assess volumetric and metabolic differences in structures implicated in this condition. the aim of this study is investigate possible metabolic (via H-1 MRS) and cortical thickness abnormalities in spider-phobic patients compared to healthy volunteers. Participants were recruited via public advertisement and underwent clinical evaluations and MRI scans. the study started in 2010 and the investigators involved were not blind in respect to patient groupings. the study was conducted at the Ribeirao Preto. Medical School University Hospital of the University of São Paulo, Brazil. Patients with spider phobia (n=19) were matched to 17 healthy volunteers with respect to age, education and socioeconomic status. the spider SP group fulfilled the diagnostic criteria for spider phobia according to the Structured Clinical Interview for DSM-IV. None of the participants had a history of neurological, psychiatric or other relevant organic diseases, use of prescribed psychotropic medication or substance abuse. All imaging and spectroscopy data were collected with a 3 T MRI scanner equipped with 25 mT gradient coils in 30-minute scans. the Freesurfer image analysis package and LC Model software were used to analyze data. the hypothesis being tested was formulated before the data collection (neural correlates of SP would include the amygdala, insula, anterior cingulate gyrus and others). the results indicated the absence of metabolic alterations, but thinning of the right anterior cingulate cortex (ACC) in the SP group when compared to the healthy control group (mean cortical thickness +/- SD: SP = 2.11 +/- 0.45 mm; HC = 2.16 +/- 0.42 mm; t (34) = 3.19, p = 0.001 [-35.45, 71.00, -23.82]). in spectroscopy, the ratios between N-acetylaspartate and creatine and choline levels were measured. No significant effect or correlation was found between MRS metabolites and scores in the Spider Phobia Questionnaire and Beck Anxiety Inventory (p > 0.05). the ACC is known to be related to the cognitive processing of fear and anxiety and to be linked with the conditioning circuit. the MRS findings are preliminary and need more studies. the finding of reduced ACC thickness in SP is in agreement with evidence from previous functional neuroimaging studies and highlights the importance of this brain area in the pathophysiology of SP. (C) 2014 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 35-42
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Brain Research
dc.rights Acesso restrito
dc.subject Specific phobia en
dc.subject Neuroimaging en
dc.subject Anxiety en
dc.subject Fear en
dc.subject ACC en
dc.title Cortical thinning of the right anterior cingulate cortex in spider phobia: A magnetic resonance imaging and spectroscopy study en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal do ABC (UFABC)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.description.affiliation Univ São Paulo, Ribeirao Preto Med Sch, Natl Inst Translat Med INCT, CNPq,Dept Neurosci & Behav, Ribeirao Preto, SP, Brazil
dc.description.affiliation Univ Fed ABC, Ctr Math Computat & Cognit, Santo Andre, Brazil
dc.description.affiliation Univ São Paulo, Ribeirao Preto Med Sch, Dept Med Clin Dept, Div Radiol, BR-14048900 Ribeirao Preto, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychiat, Lab Interdisciplinary Neurosci LINC, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Lab Neuroanat & Neuropsychobiol, Ribeirao Preto, SP, Brazil
dc.description.affiliation Univ Fed Rio de Janeiro, Inst Psychiat, Lab Pan & Respirat, Rio de Janeiro, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychiat, Lab Interdisciplinary Neurosci LINC, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2009/13557-8
dc.description.sponsorshipID FAPESP: 20102012
dc.identifier.doi 10.1016/j.brainres.2014.05.040
dc.description.source Web of Science
dc.identifier.wos WOS:000340319300004



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