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dc.contributor.authorLopes-Ferreira, Monica
dc.contributor.authorRamos, Anderson Daniel
dc.contributor.authorMartins, Itamar Alves
dc.contributor.authorLima, Carla
dc.contributor.authorConceicao, Katia [UNIFESP]
dc.contributor.authorHaddad, Vidal
dc.date.accessioned2016-01-24T14:37:41Z
dc.date.available2016-01-24T14:37:41Z
dc.date.issued2014-08-01
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2014.04.014
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 86, p. 28-39, 2014.
dc.identifier.issn0041-0101
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38058
dc.description.abstractToadfish are fish from the family Batrachoididae that are found in marine and brackish environment around the world. Among the toadfish, Porichthys genus is very common, where Porichthys porosissimus, also called Atlantic Midshipman is found in Southwest Atlantic, from Rio de Janeiro, Brazil to eastern Argentina. There was no consensus about the classification of the genus Porichthys as venomous fish because so far there are no published Studies regarding human envenomations and/or toxic activities induced in animal models. Herein, we report two conclusive envenoming in human beings caused by P porosissimus spines, with clear signs and symptoms that were very important for the development of our experimental studies. We demonstrated that the P. porosissimus spine extract, now venom, can induce nociceptive and edematogenic responses in mice as well an induction of an inflammatory response elicited by intravital microscopy and leukocyte migration. Finally, we identified in the P. porosissimus spine extract, through analysis by mass spectrometry, the presence of proteins previously detected in the venoms of other fish species and other venomous animals. We believe that based on our studies we will dismiss the non-venomous nature of this fish and clarify this issue. (C) 2014 Elsevier B.V. All rights reserved.en
dc.format.extent28-39
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.rightsAcesso restrito
dc.subjectToadfish venomen
dc.subjectPorichthys porosissimusen
dc.subjectFish venomsen
dc.subjectClinical manifestationsen
dc.subjectBitesen
dc.subjectStingsen
dc.titleClinical manifestations and experimental studies on the spine extract of the toadfish Porichthys porosissimusen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Taubate
dc.contributor.institutionUniv Estadual Paulista
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv São Paulo, Butantan Inst, Immunoregulat Unit, Special Lab Appl Toxinol CEPID FAPESP, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Immunol, São Paulo, Brazil
dc.description.affiliationUniv Taubate, Dept Biol Sci, Zool Lab, Taubate, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Dept Dermatol, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Ciencia & Tecnol, Sao Jose Dos Campos, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Ciencia & Tecnol, Sao Jose Dos Campos, Brazil
dc.identifier.doi10.1016/j.toxicon.2014.04.014
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000339035500004


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