A comparison of histamine effects on the sympathetic neurotransmission of testicular capsule and rat vas deferens

A comparison of histamine effects on the sympathetic neurotransmission of testicular capsule and rat vas deferens

Author Silva Junior, Edilson Dantas da Autor UNIFESP Google Scholar
Dantas Rodrigues, Juliano Quintella Autor UNIFESP Google Scholar
Souza, Bruno Palmieri de Autor UNIFESP Google Scholar
Caricati-Neto, Afonso Autor UNIFESP Google Scholar
Jurkiewicz, Aron Autor UNIFESP Google Scholar
Jurkiewicz, Neide H. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Histamine is an important modulatory agent of the sympathetic neurotransmission, but its exact action on the testicular capsule or rat vas deferens is not fully understood. the present study sought to further investigate the functional effects of histamine on the neuronal and exogenous noradrenaline-induced contraction of the testicular capsule and rat vas deferens as well as to evaluate the contractile properties of this drug. the testicular capsule or vas deferens from Wistar rats, 3-4 months old, weighing 300-400 g, was isolated and mounted in organ baths for functional experiments. the results indicated that the neuronally evoked contraction of the testicular capsule was affected by histamine (10(-10) to 10(-8) M) with participation of inhibitory (H-3 receptors) and excitatory (H-1 receptors) receptors. Histamine (10(-7) to 10(-4) M) modulated the field-stimulated vas deferens by excitatory (H-2 receptors) and inhibitory (H-1 receptors) receptors. Histamine was able to decrease the tonic response for noradrenaline-induced contractions with participation of H-1 receptors (testicular capsule) and H-3 receptors (vas deferens) followed by nitric oxide generation. At high concentration, histamine exerts contractile effects in both tissues. in the testicular capsule, the histamine-induced contractions were related to H-1 receptor activation followed by release of prostaglandins. in contrast, the contractile effects of histamine in the vas deferens were related to H-2 receptor activation followed by release of catecholamines from sympathetic nerve endings. Therefore, our results indicate that histamine induced several effects on the sympathetic neurotransmission of rat testicular capsule and vas deferens. These effects are dependent on the concentration used and with participation of multiple histamine receptors.
Keywords Histamine
Histamine receptors
Sympathetic neurotransmission
Testicular capsule
Vas deferens
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2014-08-01
Published in Naunyn-schmiedebergs Archives of Pharmacology. New York: Springer, v. 387, n. 8, p. 719-731, 2014.
ISSN 0028-1298 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 719-731
Origin http://dx.doi.org/10.1007/s00210-014-0979-z
Access rights Closed access
Type Article
Web of Science ID WOS:000340589200002
URI http://repositorio.unifesp.br/handle/11600/38028

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