OXA-207, a Novel OXA-24 Variant with Reduced Catalytic Efficiency against Carbapenems in Acinetobacter pittii from Spain

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Date
2014-08-01
Author
Cayô, Rodrigo [UNIFESP]
Merino, Maria
Ruiz del Castillo, Belen
Eliecer Cano, Maria
Calvo, Jorge
Bou, German
Martinez-Martinez, Luis
Type
Artigo
ISSN
0066-4804
Is part of
Antimicrobial Agents and Chemotherapy
DOI
10.1128/AAC.02633-13
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Abstract
A carbapenem-resistant Acinetobacter pittii strain carrying an OXA-24-like enzyme was isolated in northern Spain in 2008. Sequence analysis confirmed the presence of the novel bla(OXA-207) gene flanked by the site-specific XerC/XerD-like recombination binding sites and showing a unique Gly222Val substitution compared to OXA-24. Cloning and kinetic analysis showed that OXA-207 presents a reduction in the catalytic efficiency against carbapenems and a noticeable increase for oxacillin.
Citation
Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 58, n. 8, p. 4944-4948, 2014.
Sponsorship
Ministerio de Economia y Competitividad, Instituto de Salud Carlos III - European Development Regional Fund A way to achieve Europe ERDF
Spanish Network for the Research in Infectious Diseases
Fondo de Investigacion Sanitaria
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
URI
http://repositorio.unifesp.br/handle/11600/38013
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