Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone

Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone

Author Ribeiro Soares Lopes, Ione Maria Google Scholar
Maganhin, Carla Cristina Autor UNIFESP Google Scholar
Oliveira-Filho, Ricardo Martins Google Scholar
Simoes, Ricardo Santos Google Scholar
Simoes, Manuel Jesus Autor UNIFESP Google Scholar
Iwata, Margareth Chiharu Autor UNIFESP Google Scholar
Baracat, Edmund Chada Google Scholar
Soares, Jose Maria Autor UNIFESP Google Scholar
Institution Univ Fed Piaui
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Literature data indicate that the infertility in women with polycystic ovary syndrome (PCOS) is not only attributed to anovulation but also to endometrial dysfunction. Endometrial biopsies were performed in the proliferative and secretory phases of women with normal cycle and in women with PCOS before and after oral treatment with micronized progesterone. After the treatment, the endometrium of the women with PCOS exhibited a lower number of glands and thicker luminal epithelium compared to the normal women in the secretory phase. in addition, the PCOS group exhibited reduced integrin and MECA-79 immunoexpression during the secretory phase. the expression of E-cadherin was higher in the PCOS and the expression of intercellular adhesion molecule 1 was lower in PCOS, during the secretory and proliferative phases, respectively. Also, there is a negative correlation with MECA-79 and integrin expression and body mass index. Conventional doses of progesterone may not be enough to correct the changes of endometrial histomorphology and the receptive markers of PCOS-bearing women. the obesity may be a factor that interferes with this response.
Keywords polycystic ovary syndrome
endometrium
cell adhesion molecules
Language English
Date 2014-07-01
Published in Reproductive Sciences. Thousand Oaks: Sage Publications Inc, v. 21, n. 7, p. 930-938, 2014.
ISSN 1933-7191 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Inc
Extent 930-938
Origin http://dx.doi.org/10.1177/1933719113519169
Access rights Closed access
Type Article
Web of Science ID WOS:000340200300013
URI http://repositorio.unifesp.br/handle/11600/37978

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