Endovascular model of abdominal aortic aneurysm induction in swine

Endovascular model of abdominal aortic aneurysm induction in swine

Author Lederman, Alex Google Scholar
Saliture Neto, Fernando Tavares Google Scholar
Ferreira, Rimarcs Autor UNIFESP Google Scholar
Figueiredo, Luis Francisco Poli de Google Scholar
Otoch, Jose Pinhata Google Scholar
Aun, Ricardo Google Scholar
Silva, Erasmo Simao da Google Scholar
Institution Universidade de São Paulo (USP)
Hosp Israelita Albert Einstein
Universidade Federal de São Paulo (UNIFESP)
Abstract Abdominal aortic aneurysms are among the main causes of death. the high morbidity and mortality associated with aneurysm rupture and repair represents a challenge for surgeons and high risk for patients. Although experimental models are useful to understand, train, and develop new treatment and diagnostic methods for this pathology, animal models developed to date are far from ideal. Animals are either too small and do not represent the pathology of humans, or the procedures employ laparotomy, or the aortic behavior does not resemble that of a true aneurysm. We developed a novel, less invasive and effective method to induce true aortic aneurysms in Large White pigs. Animals were submitted to an endovascular chemical induction using either calcium chloride (25%) or swine pancreatic elastase. Controls were exposed to saline solution. All animals were operated on using the same surgical technique under general anesthesia. They were followed weekly with ultrasound examinations and at 4 weeks the aorta was harvested. Although elastase induced only arterial dilation, imaging, histological, and biomechanical studies of the aorta revealed the formation of true aneurysms in animals exposed to calcium chloride. Aneurysms in the latter group had biomechanical failure properties similar to those of human aneurysms. These findings indicate that the endovascular approach is viable and does not cause retroperitoneal fibrosis.
Keywords aortic aneurysm
biomechanics
calcium chloride
elastase
pig model
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2010/07307-6
Date 2014-06-01
Published in Vascular Medicine. London: Sage Publications Ltd, v. 19, n. 3, p. 167-174, 2014.
ISSN 1358-863X (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 167-174
Origin http://dx.doi.org/10.1177/1358863X14534006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000337579800002
URI http://repositorio.unifesp.br/handle/11600/37803

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