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Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil

dc.contributor.authorSoares de Araujo, Rubistenia Miranda
dc.contributor.authorVieira de Melo, Cynthia Farias
dc.contributor.authorManes Neto, Fidelis
dc.contributor.authorSilva, Juarez Nobrega da
dc.contributor.authorSoares, Leonardo Ferreira
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.authorSousa, Edilson Carvalho
dc.contributor.authorRodriguez Burbano, Rommel Mario
dc.contributor.authorMedeiros, Arnaldo Correia de
dc.contributor.authorLima, Eleonidas Moura
dc.date.accessioned2016-01-24T14:37:14Z
dc.date.available2016-01-24T14:37:14Z
dc.date.issued2014-05-01
dc.identifierhttp://dx.doi.org/10.1007/s13277-014-1656-z
dc.identifier.citationTumor Biology. Dordrecht: Springer, v. 35, n. 5, p. 4983-4986, 2014.
dc.identifier.issn1010-4283
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37722
dc.description.abstractCancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1, GSTT1, and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. the results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher's exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed (chi (2) = 8.73, P < 0.05). Our results suggest that the GSTP1 gene SNP (rs1695) can be considered a risk factor associated with gastric carcinogenesis.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent4983-4986
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofTumor Biology
dc.rightsAcesso restrito
dc.subjectSNPsen
dc.subjectGastric canceren
dc.subjectGSTP1en
dc.titleAssociation study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazilen
dc.typeArtigo
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionHosp Sao Marcos
dc.contributor.institutionState Univ Paraiba UEPB
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFed Univ Para
dc.description.affiliationFed Univ Paraiba UFPB, Dept Mol Biol, Grad Program Cellular & Mol Biol, BR-58051900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationFed Univ Paraiba UFPB, Dept Mol Biol, Lab Struct Mol Biol & Oncogenet LBMEO, BR-58051900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationFed Univ Paraiba UFPB, CCEN, Dept Mol Biol, Lab Struct Mol Biol & Oncogenet LBMEO, BR-58051900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationFed Univ Paraiba UFPB, Dept Med, BR-58051900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationHosp Sao Marcos, Dept Gastroenterol, BR-64001280 Teresina, Piaui, Brazil
dc.description.affiliationState Univ Paraiba UEPB, Dept Pharm, BR-58429500 Campina Grande, Paraiba, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationFed Univ Para, Ctr Biol Sci, Dept Biol, BR-66075110 Belem, Para, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023900 São Paulo, Brazil
dc.identifier.doi10.1007/s13277-014-1656-z
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000335759800122


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