Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin

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Date
2014-04-01
Author
Bizerra, Fernando Cesar [UNIFESP]
Jimenez-Ortigosa, Cristina
Souza, Ana Carolina R. [UNIFESP]
Breda, Giovanni Luis
Queiroz-Telles, Flavio
Perlin, David S.
Colombo, Arnaldo L. [UNIFESP]
Type
Artigo
ISSN
0066-4804
Is part of
Antimicrobial Agents and Chemotherapy
DOI
10.1128/AAC.02189-13
Metadata
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Abstract
We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them exhibited high MICs for echinocandin and azole drugs. A mutation (S663F) in hot spot 1 of the FKS2 gene was found in all five isolates. This mutation yielded a 1,3-beta-D-glucan synthase enzyme with highly reduced sensitivities to echinocandin drugs.
Citation
Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 58, n. 4, p. 2438-2440, 2014.
Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
NIH
Pfizer
Merck
Astellas
MSD
United Medical
URI
http://repositorio.unifesp.br/handle/11600/37578
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