Association of classical risk factors and coronary artery disease in type 2 diabetic patients submitted to coronary angiography

Association of classical risk factors and coronary artery disease in type 2 diabetic patients submitted to coronary angiography

Author Bittencourt, Celia Autor UNIFESP Google Scholar
Piveta, Valdecira M. Autor UNIFESP Google Scholar
Oliveira, Carolina S. V. Autor UNIFESP Google Scholar
Crispim, Felipe Autor UNIFESP Google Scholar
Meira, Deyse Autor UNIFESP Google Scholar
Saddi-Rosa, Pedro Autor UNIFESP Google Scholar
Giuffrida, Fernando M. A. Google Scholar
Reis, Andre F. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Coronary artery disease (CAD) is the leading cause of death among individuals with type 2 diabetes (T2DM). T2DM accelerates atherosclerosis alongside classical risk factors such as dyslipidemia and hypertension. This study aims to investigate the association of hyperglycemia and associated risk factors with CAD in outpatients with T2DM undergoing coronary angiography.Methods: 818 individuals referred to coronary angiography were evaluated for glucose disturbances. After exclusion of those with prediabetes, 347 individuals with T2DM and 94 normoglycemic controls were studied for BMI, blood pressure, fasting plasma glucose, HbA1c, lipids, HOMA, adiponectin, Framingham risk score, number of clinically significant coronary lesions (stenosis > 50%).Results: Among T2DM subjects, those with CAD (n = 237) had worse glycemic control (fasting glucose 162.3 + 69.8 vs. 143.4 + 48.9 mg/dL, p = 0.004; HbA1c 8.03 + 1.91 vs. 7.59 + 1.55%, p = 0.03), lower HDL (39.2 + 13.2 vs. 44.4 + 15.9 mg/dL, p = 0.003), and higher triglycerides (140 [106-204] vs. 121 [78.5-184.25] mg/dL, p = 0.002), reached more often therapeutic goals for LDL (63.4% vs. 51.4%, p = 0.037) and less often goals for HDL (26.6% vs. 37.3%, p = 0.04), when compared to CAD-free individuals (n = 110). the same differences were not seen in normoglycemic controls. in T2DM subjects HbA1c tertiles were associated with progressively higher number of significant coronary lesions (median number of lesions 2 [A1c < 6.8%]; 2.5 [A1c 6.8-8.2%]; 4 [A1c > 8.2%]; p = 0.01 for trend).Conclusions: Classic risk factors such as glycemic control and lipid profile were associated with presence of CAD in T2DM subjects undergoing coronary angiography. Glycemic control is progressively associated with number and extent of coronary lesions in patients with T2DM.
Keywords Type 2 diabetes mellitus
Risk factors
Coronary artery disease
Language English
Date 2014-03-29
Published in Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 8 p., 2014.
ISSN 1758-5996 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 8
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000334618900001

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