Ability of vitamin D to reduce inflammation in adults without acute illness
Zanetti, Mayra [UNIFESP]
Harris, Susan S.
Is part ofNutrition Reviews
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In vitro studies and some clinical studies suggest that vitamin D plays an important role in reducing inflammation. the objective of this review was to examine recent evidence that vitamin D status influences the level of inflammation in adults without acute illness or injury. Five large cross-sectional studies and two randomized controlled trials are the focus of this review. Associations between 25-hydroxyvitamin D (25OHD) and inflammation markers are significant and inverse in study populations with low 25OHD levels (<21ng/mL). They are also inverse in adults with relatively high inflammation levels. These associations in the few available randomized controlled vitamin D intervention trials have been null; this may be because they were not examined in populations with sufficiently low levels of 25OHD or high levels of inflammation. (C) 2013 International Life Sciences Institute
CitationNutrition Reviews. Hoboken: Wiley-Blackwell, v. 72, n. 2, p. 95-98, 2014.
SponsorshipU.S. Department of Agriculture
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