Active Surveillance of Candidemia in Children from Latin America A Key Requirement for Improving Disease Outcome

Active Surveillance of Candidemia in Children from Latin America A Key Requirement for Improving Disease Outcome

Author Santolaya, Maria E. Google Scholar
Alvarado, Tito Google Scholar
Queiroz-Telles, Flavio Google Scholar
Colombo, Arnaldo L. Autor UNIFESP Google Scholar
Zurita, Jeanette Google Scholar
Tiraboschi, Iris N. Google Scholar
Alberto Cortes, Jorge Google Scholar
Thompson, Luis Google Scholar
Guzman, Manuel Google Scholar
Sifuentes, Jose Google Scholar
Echevarria, Juan I. Google Scholar
Nucci, Marcio Google Scholar
Latin Amer Invasive Mycosis Networ Google Scholar
Institution Univ Chile
Hosp Escuela Tegucigalpa
Univ Fed Parana
Universidade Federal de São Paulo (UNIFESP)
Pontificia Univ Catolica Ecuador
Hosp Clin Jose San Martin
Univ Nacl Colombia
Univ Desarrollo
Hosp Vargas Caracas
Inst Nacl Ciencias Med & Nutr Salvador Zubiran
Univ Cayetano Heredia
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract Background: Active surveillance is necessary for improving the management and outcomes of patients with candidemia. the aim of this study was to describe the epidemiologic and clinical features of candidemia in pediatric patients in Latin America.Method: Prospective, multicenter, surveillance study of candidemia in a pediatric population from 23 hospitals in 8 Latin America countries between November 2008 and October 2010.Results: Three hundred and two cases of candidemia were reported with a median incidence of 0.81/1000 admissions. Eighty nine (29%) were neonates. the main risk factors were prematurity, intensive care unit (ICU) admission, parenteral nutrition, respiratory disease and mechanical ventilation in neonates and malignancy, neutropenia, neurological disease and previous use of corticosteroids in children. the main species isolated in neonates and children were Candida albicans (43.8% and 35.7%), Candida parapsilosis (27.0% and 26.3%) and Candida tropicalis (14.6% and 14.6%), respectively. the most frequent antifungal therapy used in neonates and children was deoxycholate-amphotericin-B (43.8% and 29.1%) and fluconazole (28.1% and 53.1%). Seventeen neonates (19.1%) and 20 children (9.4%) did not receive antifungal therapy. the 30-day survival rate was 60% in neonates and 72% in children (P = 0.02). Survival was significantly higher in treated than in nontreated neonates (72% vs. 24%; P < 0.001). A multivariate analysis showed that independent predictors for 30-day mortality in children were renal disease (odds ratio: 4.38, 95% confidence interval: 1.92-10.1, P < 0.001) and receipt of corticosteroids (odds ratio: 2.08, 95% confidence interval: 1.04-4.17, P = 0.04).Conclusions: To our knowledge, this is the first prospective, multicenter surveillance study of candidemia in children in Latin America. This epidemiologic information may provide us with methods to improve preventive, diagnostic and therapeutic strategies in our continent.
Keywords Candidemia
Latin America
Language English
Sponsor Pfizer Inc.
Date 2014-02-01
Published in Pediatric Infectious Disease Journal. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 2, p. E40-E44, 2014.
ISSN 0891-3668 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent E40-E44
Access rights Closed access
Type Article
Web of Science ID WOS:000331139100003

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