Study of the polymorphisms of cyclooxygenase-2 (-765G > C) and 5-lipoxygenase ( 1708G > A) in patients with colorectal cancer

Date
2014-02-01Author
Pimenta, Celia Aparecida Marques [UNIFESP]
Latini, Flavia Roche Moreira [UNIFESP]
Lima, Jacqueline Miranda de [UNIFESP]
Silva, Tiago Donizetti da [UNIFESP]
Felipe, Aledson Vitor [UNIFESP]
Pazine, Vanessa Maria de Lima [UNIFESP]
Forones, Nora Manoukian [UNIFESP]
Type
ArtigoISSN
1792-1074Is part of
Oncology LettersDOI
10.3892/ol.2013.1732Metadata
Show full item recordAbstract
Colorectal cancer (CRC) is the fourth most common cause of cancer-related mortality worldwide. Genetic alterations have been associated with an increased risk of cancer and greater tumor aggressiveness. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) genes are important in cell cycle regulation, tumor growth and prostaglandin synthesis. the aim of the present study was to investigate the association between polymorphisms in the COX-2 and 5-LOX genes and the risk of CRC. A case-control study was conducted in patients with CRC matched for gender and age to a control group. DNA was extracted from peripheral leukocytes, and the polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism and gene sequencing. A specific questionnaire was applied to evaluate smoking, excessive alcohol consumption, physical activity, non-steroidal anti-inflammatory drug use and meat, fiber and fat intake. A total of 185 patients with CRC and 146 controls were studied. the heterozygous GC genotype of the COX-2 gene polymorphism was the most common in the two groups (60.0% in CRC patients and 52.7% in controls). the CC genotype was associated with an increased risk of CRC (odds ratio, 3.63; 95% confidence interval, 1.31-10.1; P=0.013). the homozygous wild-type genotype of the 5-LOX gene polymorphism was detected in 72.4% of the CRC patients and in 71.2% of the control subjects. the homozygous mutant genotype (CC) of the COX-2 gene is an independent risk factor for CRC. No association was found between 5-LOX genotypes and CRC.
Citation
Oncology Letters. Athens: Spandidos Publ Ltd, v. 7, n. 2, p. 513-518, 2014.Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Collections
- Em verificação - Geral [7516]
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