Cardiovascular function alterations induced by acute paradoxical sleep deprivation in rats

Cardiovascular function alterations induced by acute paradoxical sleep deprivation in rats

Author Almeida, F. R. Autor UNIFESP Google Scholar
Perry, J. C. Autor UNIFESP Google Scholar
Futuro-Neto, H. A. Google Scholar
Almeida, V. R. Autor UNIFESP Google Scholar
Sebastiao, R. M. Autor UNIFESP Google Scholar
Andersen, M. L. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Campos, R. R. Autor UNIFESP Google Scholar
Bergamaschi, C. T. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Espirito Santo
Fac Brasileira Med Sch
Abstract Sleep loss has been implicated in triggering the hypertension. the goal of the present study was investigated the possible mechanisms underlying cardiovascular alterations after acute paradoxical sleep deprivation (PSD). Male Wistar rats were assigned in two experimental groups: (1) control and (2) PSD for 24 h using the modified single platform method. Paradoxical sleep deprived rats exhibited higher blood pressure, heart rate (HR) and impaired baroreceptor sensitivity. After pharmacological autonomic double blockade (propranolol and methylatropine administration), intrinsic heart rate was decreased after PSD. the PSD rats showed a reduction in the vagal tone without affecting sympathetic tone. Isoproterenol administration (0.001, 0.01 and 1 mu g/kg) induced an increase in Delta HR responses in PSD group. Electrocardiographic analysis in response to beta-adrenergic stimulation indicated that PSD contributed to ventricular cardiac arrhythmias. Our findings suggest that acute paradoxical sleep loss induce cardiovascular alterations, autonomic imbalance accompanied by impaired baroreflex sensitivity and increased arrhythmia susceptibility.
Keywords Arrhythmia
heart rate
isoproterenol
paradoxical sleep deprivation
sleep
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number CNPq: 558924/2008-5
Date 2014-01-01
Published in Clinical and Experimental Hypertension. London: Informa Healthcare, v. 36, n. 8, p. 567-571, 2014.
ISSN 1064-1963 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 567-571
Origin http://dx.doi.org/10.3109/10641963.2014.881843
Access rights Closed access
Type Article
Web of Science ID WOS:000344605600007
URI http://repositorio.unifesp.br/handle/11600/37298

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