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dc.contributor.authorZager, Adriano
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorPalermo-Neto, Joao
dc.identifier.citationNeuroimmunomodulation. Basel: Karger, v. 21, n. 1, p. 37-44, 2014.
dc.description.abstractBackground/Aims: Early life experiences are homeostatic determinants for adult organisms. We evaluated the impact of prenatal immune activation during late gestation on the neuroimmune-endocrine function of adult offspring and its interaction with acute stress. Methods: Pregnant Swiss mice received saline or lipopolysaccharide (LPS) on gestational day 17. Adult male offspring were assigned to the control or restraint stress condition. We analyzed plasmatic corticosterone and catecholamine levels, the monoamine content in the hypothalamus, striatum and frontal cortex, and the sleep-wake cycle before and after acute restraint stress. Results and Conclusion:Offspring from LPS-treated dams had increased baseline norepinephrine levels and potentiated corticosterone secretion after the acute stressor, and no effect was observed on hypothalamic monoamine content or sleep behavior. the offspring of immune-activated dams exhibited impairments in stress-induced serotonergic and dopaminergic alterations in the striatum and frontal cortex. the data demonstrate a distinction between the plasmatic levels of corticosterone in response to acute stress and the hypothalamic monoamine content and sleep patterns. We provide new evidence regarding the influence of immune activation during late gestation on the neuroendocrine homeostasis of offspring. (C) 2013 S. Karger AG, Baselen
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.rightsAcesso restrito
dc.subjectPrenatal lipopolysaccharideen
dc.subjectHypothalamic-pituitary-adrenal axisen
dc.subjectSympathoadrenal systemen
dc.subjectMonoamine contenten
dc.subjectSleep patternsen
dc.titleMaternal Immune Activation Increases the Corticosterone Response to Acute Stress without Affecting the Hypothalamic Monoamine Content and Sleep Patterns in Male Mice Offspringen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv São Paulo, FMVZ, Dept Pathol, Neuroimrnunomodulat Res Grp, BR-05508270 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 09/51886-3
dc.description.sponsorshipIDFAPESP: 09/51998-6
dc.description.sponsorshipIDFAPESP: 98/14303
dc.description.sourceWeb of Science

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