Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil

Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil

Author Candida, Thamyris Google Scholar
Franca, Jeronimo Pereira de Google Scholar
Fonseca Chaves, Alba Lucilvania Google Scholar
Rodrigues Lopes, Fernanda Andrade Google Scholar
Gaiba, Silvana Google Scholar
Sacramento, Celio Kersul do Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Franca, Lucimar Pereira de Google Scholar
Institution Univ Estadual Santa Cruz UESC
Univ Estadual Santa Cruz
Universidade Federal de São Paulo (UNIFESP)
1A CNPq
Med III CAPES
Abstract PURPOSE: To evaluate the antitumor and antimicrobial activity of ethanolic extract of Morinda citrifolia L. fruit cultivated in southeastern Brazil.METHODS: Preparation ethanolic extract of the fruit of Morinda citrifolia L. Culture of melanoma cells B16-F10 for treatment with ethanolic extract of Morinda citrifolia L. fruit to determine cell viability by MTT and determination temporal effect of ethanolic extract fruit on the cell growth B16-F10 for 8 days. Evaluation of antimicrobial activity of ethanolic extract fruit against Staphylococcus aureus and Escherichia coli by determination of Minimum Inhibitory Concentration (MIC).RESULTS: the ethanolic extract of Morinda citrifolia L. fruit (10mg/mL) decreased cellular activity and inhibited 45% the rate of cell proliferation of B16-F10 melanoma treated during period studied. the ethanolic extract of Morinda citrifolia L. fruit demonstrated antimicrobial activity inhibiting the growth of both microorganisms studied. Staphylococcus aureus was less resistant to ethanolic extract of Morinda citrifolia L. fruit than Escherichia coli, 1 mg/mL and 10 mg/mL, respectively.CONCLUSION: What these results indicate that the ethanolic extract of the fruit of Morinda citrifolia L. showed antitumor activity with inhibition of viability and growth of B16-F10 cells and also showed antibacterial activity as induced inhibition of growth of Staphylococcus aureus and Escherichia coli.
Keywords Morinda citrifolia L.
Morinda
Drug Screening Assays Antitumor
Anti-Infective Agents
Antimicrobial
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Bahia Research Foundation (FAPESB)
Date 2014-01-01
Published in Acta Cirurgica Brasileira. São Paulo: Acta Cirurgica Brasileira, v. 29, p. 10-14, 2014.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 10-14
Origin http://dx.doi.org/10.1590/S0102-86502014001400003
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000342065300004
SciELO ID S0102-86502014001400003 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/37175

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