State of the Art in the Studies on Crotamine, a Cell Penetrating Peptide from South American Rattlesnake

State of the Art in the Studies on Crotamine, a Cell Penetrating Peptide from South American Rattlesnake

Author Kerkis, Irina Google Scholar
Hayashi, Mirian A. F. Autor UNIFESP Google Scholar
Prieto da Silva, Alvaro R. B. Google Scholar
Pereira, Alexandre Google Scholar
De Sa Junior, Paulo Luiz Google Scholar
Zaharenko, Andre J. Google Scholar
Radis-Baptista, Gandhi Google Scholar
Kerkis, Alexandre Google Scholar
Yamane, Tetsuo Google Scholar
Institution Inst Butantan
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Ceara
Univ Estado Amazonas
CBA
Abstract Animal venoms comprise a naturally selected cocktail of bioactive peptides/proteins and other molecules, each of which playing a defined role thanks to the highly specific interactions with diverse molecular targets found in the prey. Research focused on isolation, structural, and functional characterizations of novel natural biologics (bioactive peptides/proteins from natural sources) has a long way to go through from the basic science to clinical applications. Herein, we overview the structural and functional characteristics of the myoneurotoxin crotamine, firstly isolated from the South American rattlesnake venom. Crotamine is the first venom peptide classified as a natural cell penetrating and antimicrobial peptide (CPP and AMP) with a more pronounced antifungal activity. in contrast to other known natural CPPs and AMPs, crotamine demonstrates a wide spectrum of biological activities with potential biotechnological and therapeutic values. More recent studies have demonstrated the selective in vitro anticancer activity of crotamine. in vivo, using a murine melanoma model, it was shown that crotamine delays tumor implantation, inhibits tumor cells proliferation, and also increases the survival of mice engrafted with subcutaneous melanoma. the structural and functional properties and also the possible biotechnological applications of minimized molecules derived from crotamine are also discussed.
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2014-01-01
Published in Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2014.
ISSN 2314-6133 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 9
Origin http://dx.doi.org/10.1155/2014/675985
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000330478700001
URI http://repositorio.unifesp.br/handle/11600/37150

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