Anti-VEGF for the Management of Diabetic Macular Edema

Anti-VEGF for the Management of Diabetic Macular Edema

Author Stefanini, Francisco Rosa Autor UNIFESP Google Scholar
Badaro, Emmerson Autor UNIFESP Google Scholar
Falabella, Paulo Autor UNIFESP Google Scholar
Koss, Michael Google Scholar
Farah, Michel Eid Autor UNIFESP Google Scholar
Maia, Mauricio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ So Calif
Goethe Univ Frankfurt
Abstract Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most frequent cause of vision impairment and represents a significant public health issue. Macular photocoagulation has been the standard treatment for this condition reducing the risk of moderate visual loss by approximately 50%. the role of vascular endothelial growth factor (VEGF) in DR and DME pathogenesis has been demonstrated in recent studies. This review addresses and summarizes data from the clinical trials that investigated anti-VEGF for the management of DME and evaluates their impact on clinical practice. the literature searches were conducted between August and October 2013 in PubMed and Cochrane Library with no date restrictions and went through the most relevant studies on pegaptanib, ranibizumab, bevacizumab, and aflibercept for the management of DME. the efficacy and safety of intravitreal anti-VEGF as therapy for DME have recently been proved by various clinical trials providing significantly positive visual and anatomical results. Regarding clinical practice, those outcomes have placed intravitreal injection of anti-VEGF as an option that must be considered for the treatment of DME.
Language English
Date 2014-01-01
Published in Journal of Immunology Research. New York: Hindawi Publishing Corporation, 8 p., 2014.
ISSN 2314-8861 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 8
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000332544000001

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