The Effect of Different Photoperiods in Circadian Rhythms of Per3 Knockout Mice

The Effect of Different Photoperiods in Circadian Rhythms of Per3 Knockout Mice

Author Pereira, D. S. Autor UNIFESP Google Scholar
van der Veen, D. R. Google Scholar
Goncalves, B. S. B. Google Scholar
Tufik, S. Autor UNIFESP Google Scholar
von Schantz, M. Google Scholar
Archer, S. N. Google Scholar
Pedrazzoli, M. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Surrey
Univ Fed Rio Grande do Norte
Inst Fed Sudeste Minas Gerais
Universidade de São Paulo (USP)
Abstract The aim of this study was to analyse the circadian behavioural responses of mice carrying a functional knockout of the Per3 gene (Per3(-/-)) to different light : dark (L : D) cycles. Male adult wild- type (WT) and Per3(-/-) mice were kept under 12- hour light : 12hour dark conditions (12L : 12D) and then transferred to either a short or long photoperiod and subsequently released into total darkness. All micewere exposed to both conditions, and behavioural activity datawere acquired through runningwheel activity and analysed for circadian characteristics during these conditions. We observed that, during the transition from 12L : 12D to 16L : 8D, Per3(-/-)mice take approximately one additional day to synchronise to the new L : D cycle compared toWT mice. Under these long photoperiod conditions, Per3(-/-) mice were more active in the light phase. Our results suggest that Per3(-/-) mice are less sensitive to light. the data presented here provides further evidence that Per3 is involved in the suppression of behavioural activity in direct response to light.
Language English
Sponsor Biotechnology and Biological Sciences Research Council (BBSRC)
Royal Society (Malcolm von Schantz)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number Biotechnology and Biological Sciences Research Council (BBSRC): BB/E003672/1
FAPESP: 2007/05037-9
FAPESP: CEPID 98/14303-3
Date 2014-01-01
Published in Biomed Research International. New York: Hindawi Publishing Corporation, 5 p., 2014.
ISSN 2314-6133 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 5
Origin http://dx.doi.org/10.1155/2014/170795
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000336153400001
URI http://repositorio.unifesp.br/handle/11600/37128

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