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dc.contributor.authorPires, Vanessa Cardoso [UNIFESP]
dc.contributor.authorBoiago Golluecke, Andrea Pittelli
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorLungato, Lisandro [UNIFESP]
dc.contributor.authorD'Almeida, Vania [UNIFESP]
dc.contributor.authorAguiar, Odair [UNIFESP]
dc.date.accessioned2016-01-24T14:34:51Z
dc.date.available2016-01-24T14:34:51Z
dc.date.issued2013-12-14
dc.identifierhttp://dx.doi.org/10.1017/S0007114513001360
dc.identifier.citationBritish Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 110, n. 11, p. 2020-2029, 2013.
dc.identifier.issn0007-1145
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37082
dc.description.abstractThe aim of the present study was to investigate the effects of long-term grape juice concentrate (GJC) consumption, in two dosages, on the reproductive parameters of cadmium-exposed male rats. the effects of the concentrate on body mass gain, plasma testosterone levels, reproductive organ weights, daily sperm production, sperm morphology, testis histopathological and histomorphometrical parameters, and testicular antioxidant markers were investigated. Wistar rats (n 54) were distributed into six groups: CdCl2; cadmium and grape juice I (1.18 g/kg per d); cadmium and grape juice II (2.36 g/kg per d); grape juice I (1.18 g/kg per d); grape juice II (2.36 g/kg per d); control. A single dose of CdCl2 (1.2 mg/kg body weight (BW)) was injected intraperitoneally and the grape juice was administered orally for 56 d. the results indicated that cadmium changed all reproductive and antioxidant parameters. At dosage I (1.18 g/kg BW), GJC consumption did not show the effects against cadmium-induced damages. in contrast, at dosage II (2.36 g/kg BW), the GJC improved the gonadosomatic index (P=0.003), serum testosterone levels (P=0.001), the relative weight of epididymis (P=0.013) and ventral prostate (P=0.052), the percentage of normal sperm (P=0.001), and histopathological and histomorphometrical parameters. in addition, at this dosage, normalisation of the enzymatic activity of superoxide dismutase (P=0.001) and of testicular levels of glutathione (P=0.03) were observed. the parameters of the non-exposed rats did not depict significant alterations. in conclusion, the product was able to act as a protector of reproductive function against cadmium-induced damage. Such a property was expressed in a dose-dependent manner as the more effective dose was dosage II. the GJC acted possibly by antioxidant mechanisms.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent2020-2029
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofBritish Journal of Nutrition
dc.rightsAcesso restrito
dc.subjectFunctional foodsen
dc.subjectReproductionen
dc.subjectCadmiumen
dc.titleGrape juice concentrate protects reproductive parameters of male rats against cadmium-induced damage: a chronic assayen
dc.typeArtigo
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Catolica Santos
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Catolica Santos, Hexalab, Santos, SP, Brazil
dc.description.affiliationUniv Catolica Santos, Dept Nutr, Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2011/22811-5
dc.description.sponsorshipIDFAPESP: 2011/03873-0
dc.identifier.doi10.1017/S0007114513001360
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000330345900011


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