Is there an association between cortical thickness, age of onset, and duration of illness in schizophrenia?

Is there an association between cortical thickness, age of onset, and duration of illness in schizophrenia?

Author Assuncao Leme, Idaiane Batista Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Sato, Joao Ricardo Google Scholar
Ota, Vanessa Kiyomi Autor UNIFESP Google Scholar
Mari, Jair de Jesus Autor UNIFESP Google Scholar
Melaragno, Maria Isabel Autor UNIFESP Google Scholar
Cardoso Smith, Marilia de Arruda Autor UNIFESP Google Scholar
Nogueira Belangero, Sintia Iole Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC (UFABC)
Abstract Objective Several studies have shown cortical volume loss in frontotemporal regions in schizophrenia patients, and it is known that these reductions may be associated with disease symptoms and cognitive deficits. the aim of this study was to investigate possible cortical thickness correlations in frontotemporal regions in relation to age at onset and duration of illness.Methods One hundred forty-eight schizophrenia patients (97 males; age and SD 36.30 +/- 10.06) and 87 (57 males; age and SD 36.48 +/- 10.10) age-matched healthy subjects underwent a brain MRI scan. Cortical segmentation and surface statistical analysis were performed using the FreeSurfer software package. Results were corrected for multiple comparisons using the Monte Carlo method considering a cluster-corrected Type I Error of 5%.Results Compared to controls, schizophrenia patients presented significant cortical thinning in the frontotemporal, parietal, and occipital cortices. No correlation between prefrontal cortex thickness and duration of illness in patients with schizophrenia or between frontotemporal cortical thickness and age at onset was found. However, a significant interaction between age and diagnosis was observed on frontal cortical thickness with patients presenting a thinner cortex than expected for age.Conclusion Although there was no correlation between age of onset and duration of illness with brain volume, our findings suggest that there is an accelerated cortical loss in schizophrenia, thus reinforcing the progressive processes of the disease.
Keywords Age
age at onset
cortical thickness
duration of illness
frontal lobe
Language English
Sponsor Roche
Date 2013-12-01
Published in Cns Spectrums. New York: Cambridge Univ Press, v. 18, n. 6, p. 315-321, 2013.
ISSN 1092-8529 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 315-321
Access rights Closed access
Type Article
Web of Science ID WOS:000327777100005

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