Psychopharmacology and psychotherapy for the treatment of adults with ADHD-a systematic review of available meta-analyses

Psychopharmacology and psychotherapy for the treatment of adults with ADHD-a systematic review of available meta-analyses

Author Moriyama, Tais S. Autor UNIFESP Google Scholar
Polanczyk, Guilherme V. Google Scholar
Terzi, Fernanda S. Google Scholar
Faria, Kauy M. Google Scholar
Rohde, Luis A. Google Scholar
Institution Natl Inst Dev Psychiat Children & Adolescents INC
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Fed Rio Grande do Sul
Abstract Objective/Introduction Attention-deficit/hyperactivity disorder (ADHD) in adult life is a prevalent condition. We systematically reviewed the literature available by searching for meta-analyses assessing pharmacological and psychosocial interventions for adults with ADHD.Methods Using wide-ranging search terms, we retrieved 191 titles from the PubMed and Cochrane databases. Two independent evaluators judged all abstracts. Only meta-analyses about the treatment of adults with ADHD were included. Information from meta-analyses found was systematically extracted by 3 independent evaluators.Results Eight meta-analyses were identified. Results from those meta-analyses suggest that stimulants are effective in decreasing ADHD symptoms on a short-term basis with a medium to large effect size (ES). Short-acting stimulants might be superior to long-acting stimulants, but no data on difference in adherence are available for the comparison of these two types of formulation. Bupropion is superior to placebo but less effective than stimulants. No conclusions about the impact of psychosocial interventions can be drawn based on meta-analyses so far.Discussion the efficacy of stimulants in reducing ADHD symptoms for adults is well documented in meta-analyses, but there is a concerning lack of meta-analysis about other treatment interventions.Conclusion the available meta-analytic literature does not cover questions of essential clinical relevance for adults with ADHD.
Keywords ADHD
Language English
Sponsor Novartis
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-12-01
Published in Cns Spectrums. New York: Cambridge Univ Press, v. 18, n. 6, p. 296-306, 2013.
ISSN 1092-8529 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 296-306
Access rights Closed access
Type Review
Web of Science ID WOS:000327777100003

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